Injectable Nanocomposite Implants Reduce ROS Accumulation and Improve Heart Function after Infarction

Malka Shilo, Hadas Oved, Lior Wertheim, Idan Gal, Nadav Noor, Ori Green, Ester Sapir Baruch, Doron Shabat, Assaf Shapira, Tal Dvir*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

In a myocardial infarction, blood supply to the left ventricle is abrogated due to blockage of one of the coronary arteries, leading to ischemia, which further triggers the generation of reactive oxygen species (ROS). These sequential processes eventually lead to the death of contractile cells and affect the integrity of blood vessels, resulting in the formation of scar tissue. A new heart therapy comprised of cardiac implants encapsulated within an injectable extracellular matrix-gold nanoparticle composite hydrogel is reported. The particles on the collagenous fibers within the hydrogel promote fast transfer of electrical signal between cardiac cells, leading to the functional assembly of the cardiac implants. The composite hydrogel is shown to absorb reactive oxygen species in vitro and in vivo in mice ischemia reperfusion model. The reduction in ROS levels preserve cardiac tissue morphology and blood vessel integrity, reduce the scar size and the inflammatory response, and significantly prevent the deterioration of heart function.

Original languageEnglish
Article number2102919
JournalAdvanced Science
Volume8
Issue number24
DOIs
StatePublished - 22 Dec 2021

Funding

FundersFunder number
Slezak Foundation
Moxie Foundation
European Research Council637943
Ministry of Science, Technology and Space
Israel Science Foundation700/13

    Keywords

    • cardiac tissue engineering
    • gold nanoparticles
    • heart disease
    • hydrogel
    • myocardial infarction

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