Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine

Matan Levine-Tiefenbrun; Idan Yelin; Rachel Katz; Esma Herzel; Ziv Golan; Licita Schreiber; Tamar Wolf; Varda Nadler; Amir Ben-Tov; Jacob Kuint; Sivan Gazit; Tal Patalon; Gabriel Chodick; Roy Kishony

doi:10.1038/s41591-021-01316-7

Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine

Matan Levine-Tiefenbrun, Idan Yelin^*, Rachel Katz, Esma Herzel, Ziv Golan, Licita Schreiber, Tamar Wolf, Varda Nadler, Amir Ben-Tov, Jacob Kuint, Sivan Gazit, Tal Patalon, Gabriel Chodick, Roy Kishony^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

344 Scopus citations

Abstract

Beyond their substantial protection of individual vaccinees, coronavirus disease 2019 (COVID-19) vaccines might reduce viral load in breakthrough infection and thereby further suppress onward transmission. In this analysis of a real-world dataset of positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test results after inoculation with the BNT162b2 messenger RNA vaccine, we found that the viral load was substantially reduced for infections occurring 12–37 d after the first dose of vaccine. These reduced viral loads hint at a potentially lower infectiousness, further contributing to vaccine effect on virus spread.

Original language	English
Pages (from-to)	790-792
Number of pages	3
Journal	Nature Medicine
Volume	27
Issue number	5
DOIs	https://doi.org/10.1038/s41591-021-01316-7
State	Published - May 2021

Funding

Funders	Funder number
Israel Science Foundation	3633/19

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41591-021-01316-7

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abstract = "Beyond their substantial protection of individual vaccinees, coronavirus disease 2019 (COVID-19) vaccines might reduce viral load in breakthrough infection and thereby further suppress onward transmission. In this analysis of a real-world dataset of positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test results after inoculation with the BNT162b2 messenger RNA vaccine, we found that the viral load was substantially reduced for infections occurring 12–37 d after the first dose of vaccine. These reduced viral loads hint at a potentially lower infectiousness, further contributing to vaccine effect on virus spread.",

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AU - Golan, Ziv

AU - Schreiber, Licita

AU - Wolf, Tamar

AU - Nadler, Varda

AU - Ben-Tov, Amir

AU - Kuint, Jacob

AU - Gazit, Sivan

AU - Patalon, Tal

AU - Chodick, Gabriel

AU - Kishony, Roy

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Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine

Abstract

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UN SDGs

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