TY - JOUR
T1 - Inhibitory receptors on myeloid cells
T2 - New targets for therapy?
AU - Munitz, Ariel
N1 - Funding Information:
Grant support: This work was supported by a Research Fellowship Award from the American Heart Association and internal Tel-Aviv University Funds .
PY - 2010/1
Y1 - 2010/1
N2 - Immune regulation of cellular activation is a tightly regulated process dictated by a balance of activation and inhibitory signals. Although initially described and characterized on natural killer cells, it has become increasingly apparent that inhibitory receptors are expressed and functional on myeloid cells. These receptors can override signals elicited by activation pathways including cytokine and chemokine receptors, growth factor signaling and more recently innate immune receptor signaling. Inhibitory receptors have key roles in various cellular and pathological processes and are thus potential targets for future therapeutics. In this review, the structure and function of inhibitory receptors will be discussed. Furthermore, utilization of these receptors as pharmacological targets and recent examples of strategies targeting inhibitory receptors will be analyzed.
AB - Immune regulation of cellular activation is a tightly regulated process dictated by a balance of activation and inhibitory signals. Although initially described and characterized on natural killer cells, it has become increasingly apparent that inhibitory receptors are expressed and functional on myeloid cells. These receptors can override signals elicited by activation pathways including cytokine and chemokine receptors, growth factor signaling and more recently innate immune receptor signaling. Inhibitory receptors have key roles in various cellular and pathological processes and are thus potential targets for future therapeutics. In this review, the structure and function of inhibitory receptors will be discussed. Furthermore, utilization of these receptors as pharmacological targets and recent examples of strategies targeting inhibitory receptors will be analyzed.
KW - Immunoreceptor tyrosine-based inhibitory motif (ITIM)
KW - Inflammation
KW - Inhibitory receptor
KW - Myeloid cells
UR - http://www.scopus.com/inward/record.url?scp=72049132624&partnerID=8YFLogxK
U2 - 10.1016/j.pharmthera.2009.10.007
DO - 10.1016/j.pharmthera.2009.10.007
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C2 - 19913051
AN - SCOPUS:72049132624
SN - 0163-7258
VL - 125
SP - 128
EP - 137
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
IS - 1
ER -
