Inhibitory effect of ileal oleate on postprandial motility of the upper gut

Z. Dreznik, D. Brocksmith, T. A. Meininger, N. J. Soper*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


To determine the effect of ileal oleate on postprandial gastrointestinal motility, duodenal and paired perfusion-aspiration ileal catheters and bipolar duodenal and jejunal electrodes were surgically implanted in five dogs. The ileum was perfused with either saline or an isotonic oleic acid emulsion at 2 ml/min. A 205-kcal mixed meal containing 120 ml liquid nutrient labeled with 111In-diethylenetriamine pentaacetic acid (DTPA) and solid food labeled with 99mTc was then administered orally. Gastric emptying was assessed by a gamma camera, myoelectric activity was continuously monitored, and duodenal-ileal transit of phenol red was determined over the ensuing 240 min. Ileal oleate reduced duodenal spikeburst frequency by 50% (P < 0.05) and delayed gastric emptying of liquids and solids. Four hours after ingesting the meal, 62% of solids and 34% of liquids were retained in the stomach during oleic acid perfusion compared with 25 and 4%, respectively, when saline was perfused (P < 0.05). Duodenal-ileal transit was markedly slowed by ileal perfusion with the oleic acid emulsion (P < 0.001). Ileal oleate therefore exerted a profound inhibitory effect on proximal gut motility in the early period after ingestion of a mixed-nutrient meal in dogs.

Original languageEnglish
Pages (from-to)G458-G463
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Issue number3 24-3
StatePublished - 1991
Externally publishedYes


FundersFunder number
National Center for Research ResourcesS07RR005389


    • Gastric emptying
    • Oleic acid


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