Inhibitory effect of a high-molecular-weight constituent of cranberry on adhesion of oral bacteria

E. I. Weiss, R. Lev-Dor, Nathan Sharon, Itzhak Ofek

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

A high-molecular-weight nondialysable material (NDM) isolated from cranberry juice at a concentration of 0.6 to 2.5 mg/ml dissociated coaggregates formed by many intergeneric oral bacteria. A lower concentration of NDM was required to inhibit formation of such coaggregates. NDM acted preferentially on pairs of oral bacteria in which one or both members are Gram-negative anaerobes. The high-molecular-weight material from blueberry also inhibited the coaggregation, although its activity was weaker, whereas such materials obtained from other fruits were inactive. Saliva did not interfere with the ability of NDM to inhibit coaggregation. A preliminary clinical trial showed that NDM reduces S. mutans counts in saliva. The antiadhesion activity of cranberry juice has a potential for altering the oral microbial flora resulting in improved oral hygiene.

Original languageEnglish
Pages (from-to)285-292
Number of pages8
JournalCritical Reviews in Food Science and Nutrition
Volume42
Issue number3
DOIs
StatePublished - 2002

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