Inhibition of vacuolar H+-ATPases by fusidic acid and suramin

Yoshinori Moriyama*, Nathan Nelson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The vacuolar system of eukaryotic cells is energized by a few ATP-driven ion pumps. One of these, the H+-ATPase, plays a major role in providing the protonmotive force for several organelles, as well as maintaining the proper pH inside the organelles. Formation of the protonmotive force in organelles isolated from the vacuolar system was inhibited by fusidic acid. The inhibition results from a combination of uncoupling the proton pumping and inhibition of the H+-ATPase activity. Suramin is also a potent inhibitor of the H+-ATPase from chromaffin granules. A possible connection between these activities and inhibition of HIV infection is pointed out.

Original languageEnglish
Pages (from-to)383-386
Number of pages4
JournalFEBS Letters
Volume234
Issue number2
DOIs
StatePublished - 18 Jul 1988
Externally publishedYes

Keywords

  • Enzyme inhibitor
  • Fusidic acid
  • H-ATPase
  • Suramin

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