Inhibition of protein synthesis by glutathione disulfide in the presence of glutathione

Nechama S. Kosower*, Grace A. Vanderhoff, Barry Benerofe, Tim Hunt, Edward M. Kosower

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

As little as 5 × 10-5 M glutathione disulfide (GSSG) in the presence of 80 × 10-5 M glutathione (GSH) in a rabbit reticulocyte lysate caused a profound inhibition of initiation of protein synthesis. A potential physiological regulatory role for GSSG in protein synthesis is thus revealed.

Original languageEnglish
Pages (from-to)816-821
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume45
Issue number3
DOIs
StatePublished - 5 Nov 1971
Externally publishedYes

Fingerprint

Dive into the research topics of 'Inhibition of protein synthesis by glutathione disulfide in the presence of glutathione'. Together they form a unique fingerprint.

Cite this