Inhibition of Nonfunctional Ras

Ruth Nussinov, Hyunbum Jang, Attila Gursoy, Ozlem Keskin, Vadim Gaponenko

Research output: Contribution to journalReview articlepeer-review

Abstract

Nussinov et al. describe that the mechanism of mutational activation of kinases differs from Ras. Drug action should relate to the mechanism of activation, not to whether the protein is in active or inactive state. However, allosterically blocking the functional site will work for the inactive kinase and active Ras.

Original languageEnglish
Pages (from-to)121-133
Number of pages13
JournalCell Chemical Biology
Volume28
Issue number2
DOIs
StatePublished - 18 Feb 2021

Keywords

  • K-Ras4B
  • KRAS
  • dimer
  • drug discovery
  • energy landscape
  • inhibitor
  • kinases

Fingerprint

Dive into the research topics of 'Inhibition of Nonfunctional Ras'. Together they form a unique fingerprint.

Cite this