Inhibition of Nonfunctional Ras

Ruth Nussinov*, Hyunbum Jang, Attila Gursoy, Ozlem Keskin, Vadim Gaponenko*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Nussinov et al. describe that the mechanism of mutational activation of kinases differs from Ras. Drug action should relate to the mechanism of activation, not to whether the protein is in active or inactive state. However, allosterically blocking the functional site will work for the inactive kinase and active Ras.

Original languageEnglish
Pages (from-to)121-133
Number of pages13
JournalCell Chemical Biology
Issue number2
StatePublished - 18 Feb 2021


  • K-Ras4B
  • KRAS
  • dimer
  • drug discovery
  • energy landscape
  • inhibitor
  • kinases


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