Inhibition of mating by naloxone or morphine in recently castrated, but not intact male rats

I. Lieblich, M. J. Baum*, P. Diamond, N. Goldblum, C. Iser, C. G. Pick

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Administration of naloxone (SC 5 mg/kg) significantly reduced ejaculation and mounting in male rats in the weeks following castration. A similar effect was obtained by injecting morphine (SC 1 or 5 mg/kg). In contrast, the same dosages of naloxone or morphine did not affect the sexual performance of gonadally intact males. Opioid peptides may contribute to the temporary persistence of sexual behavior in testosterone-deficient male mammals, in which incentive qualities of the female partner are an important determinant of sexual arousal.

Original languageEnglish
Pages (from-to)361-364
Number of pages4
JournalPharmacology Biochemistry and Behavior
Volume22
Issue number3
DOIs
StatePublished - Mar 1985
Externally publishedYes

Keywords

  • Endophins
  • Morphine
  • Naloxone
  • Rat sexual behavior

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