Inhibition of mating by naloxone or morphine in recently castrated, but not intact male rats

I. Lieblich, M. J. Baum, P. Diamond, N. Goldblum, C. Iser, C. G. Pick

Research output: Contribution to journalArticlepeer-review

Abstract

Administration of naloxone (SC 5 mg/kg) significantly reduced ejaculation and mounting in male rats in the weeks following castration. A similar effect was obtained by injecting morphine (SC 1 or 5 mg/kg). In contrast, the same dosages of naloxone or morphine did not affect the sexual performance of gonadally intact males. Opioid peptides may contribute to the temporary persistence of sexual behavior in testosterone-deficient male mammals, in which incentive qualities of the female partner are an important determinant of sexual arousal.

Original languageEnglish
Pages (from-to)361-364
Number of pages4
JournalPharmacology Biochemistry and Behavior
Volume22
Issue number3
DOIs
StatePublished - Mar 1985
Externally publishedYes

Keywords

  • Endophins
  • Morphine
  • Naloxone
  • Rat sexual behavior

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