Inhibition of human red blood cell glutathione reductase by valproic acid

Dita Cotariu, Sandra Evans, Eliezer Lahat, Jack Theitler, Tsvy Bistritzer, Jacob L. Zaidman

Research output: Contribution to journalArticlepeer-review

Abstract

Glutathione reductase (GR) one of the enzymes of the glutathione redox cycle, plays a salient role in maintaining appropriate cellular levels of reduced glutathione. The enzyme in human red blood cells is inhibited in vitro by the anticonvulsant drug valproic acid (VPA). The inhibition is dose-dependent, reversible, uncompetitive and does not depend on the redox state of the enzyme. VPA also inhibits red blood cell GR activity in children being treated with the drug. The level of serum VPA correlates significantly with the suppression of GR activity.

Original languageEnglish
Pages (from-to)425-429
Number of pages5
JournalBiochemical Pharmacology
Volume43
Issue number3
DOIs
StatePublished - 4 Feb 1992

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