TY - JOUR
T1 - Inhibition of human red blood cell glutathione reductase by valproic acid
AU - Cotariu, Dita
AU - Evans, Sandra
AU - Lahat, Eliezer
AU - Theitler, Jack
AU - Bistritzer, Tsvy
AU - Zaidman, Jacob L.
PY - 1992/2/4
Y1 - 1992/2/4
N2 - Glutathione reductase (GR) one of the enzymes of the glutathione redox cycle, plays a salient role in maintaining appropriate cellular levels of reduced glutathione. The enzyme in human red blood cells is inhibited in vitro by the anticonvulsant drug valproic acid (VPA). The inhibition is dose-dependent, reversible, uncompetitive and does not depend on the redox state of the enzyme. VPA also inhibits red blood cell GR activity in children being treated with the drug. The level of serum VPA correlates significantly with the suppression of GR activity.
AB - Glutathione reductase (GR) one of the enzymes of the glutathione redox cycle, plays a salient role in maintaining appropriate cellular levels of reduced glutathione. The enzyme in human red blood cells is inhibited in vitro by the anticonvulsant drug valproic acid (VPA). The inhibition is dose-dependent, reversible, uncompetitive and does not depend on the redox state of the enzyme. VPA also inhibits red blood cell GR activity in children being treated with the drug. The level of serum VPA correlates significantly with the suppression of GR activity.
UR - http://www.scopus.com/inward/record.url?scp=0026595086&partnerID=8YFLogxK
U2 - 10.1016/0006-2952(92)90559-2
DO - 10.1016/0006-2952(92)90559-2
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AN - SCOPUS:0026595086
VL - 43
SP - 425
EP - 429
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
SN - 0006-2952
IS - 3
ER -