Inhibition of human platelet mitochondrial protein synthesis by chloramphenicol

G. Agam, M. Djaldetti

Research output: Contribution to journalArticlepeer-review


Human platelet mitochrondial protein synthesis, assayed by 'in vitro' 3H leucine incorporation into the protein moiety of isolated mitochondria, was shown to be inhibited by a therapeutic concentration of chloramphenical (CAP). This finding is in accordance with the ultrastructural damage caused to these organelles by the antibiotic, and with the inhibition of mitochondrial protein synthesis found in other kinds of mammalian cells.

Original languageEnglish
Pages (from-to)66-69
Number of pages4
JournalBiomedicine Express
Issue number2
StatePublished - 1977
Externally publishedYes


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