Inhibition of herpes simplex virus strains isolated from herpetic keratitis by polyinosinic acid polycytidylic acid

O. Smetana, E. Eylan, M. Weinberg

Research output: Contribution to journalArticlepeer-review

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Abstract

Fifty strains of herpes simplex virus, isolated from patients with herpetic keratitis, were examined in vitro for susceptibility to polyinosinic acid-polycytidylic acid [poly (I:C)] in the presence of a constant concentration of diethylaminoethyl-dextran. The minimal inhibitory concentration of poly (I:C) for 44 of these strains ranged from 0.0001 to 0.1 μg/ml; for the remaining six strains, the minimal inhibitory concentration stood at 1 to 2 μg/ml. Fifteen isolates from primary infections were more susceptible to poly (I:C) than 35 isolates from recurrent infections. Isolates acquired at different points of a given clinical episode showed similar susceptibilities to poly (I:C). In two patients, isolates from consecutive recurrences of infection exhibited reduced susceptibilities. The implications of the above observations for the therapeutic use of poly (I:C) are discussed.

Original languageEnglish
Pages (from-to)797-802
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Volume11
Issue number5
DOIs
StatePublished - 1977

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