TY - JOUR
T1 - Inhibition of experimental porphyria with colchicine
AU - Wysenbeek, A. J.
AU - Schoenfeld, N.
AU - Epstein, O.
AU - Greenblat, Y.
AU - Atsmon, A.
PY - 1985
Y1 - 1985
N2 - 1. 1. Colchicine at the concentrations of 5 × 10-7-5 × 10-6M decreased significantly both delta-aminolevulinic acid synthase activity and accumulation of porphyrins in monolayers of chick embryo liver cells induced by allyl-isopropylacetamide, by 3,5-diethoxycarbonyl-1,4-dihydrocollidine or by phenobarbitone. 2. 2. No effect was noted in non-induced cells. 3. 3. In rats, colchicine 0.3 mg/kg, reduced significantly the allyl-isopropylacetamide induced increase in the activity of delta-aminolevulinic acid synthase in the liver and the concentration of urinary porphyrins while it did not affect these parameters in non-induced rats.
AB - 1. 1. Colchicine at the concentrations of 5 × 10-7-5 × 10-6M decreased significantly both delta-aminolevulinic acid synthase activity and accumulation of porphyrins in monolayers of chick embryo liver cells induced by allyl-isopropylacetamide, by 3,5-diethoxycarbonyl-1,4-dihydrocollidine or by phenobarbitone. 2. 2. No effect was noted in non-induced cells. 3. 3. In rats, colchicine 0.3 mg/kg, reduced significantly the allyl-isopropylacetamide induced increase in the activity of delta-aminolevulinic acid synthase in the liver and the concentration of urinary porphyrins while it did not affect these parameters in non-induced rats.
UR - http://www.scopus.com/inward/record.url?scp=0022260416&partnerID=8YFLogxK
U2 - 10.1016/0020-711X(85)90179-X
DO - 10.1016/0020-711X(85)90179-X
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AN - SCOPUS:0022260416
SN - 0020-711X
VL - 17
SP - 937
EP - 940
JO - International Journal of Biochemistry
JF - International Journal of Biochemistry
IS - 8
ER -