Inhibition of experimental porphyria with colchicine

A. J. Wysenbeek, N. Schoenfeld, O. Epstein, Y. Greenblat, A. Atsmon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

1. 1. Colchicine at the concentrations of 5 × 10-7-5 × 10-6M decreased significantly both delta-aminolevulinic acid synthase activity and accumulation of porphyrins in monolayers of chick embryo liver cells induced by allyl-isopropylacetamide, by 3,5-diethoxycarbonyl-1,4-dihydrocollidine or by phenobarbitone. 2. 2. No effect was noted in non-induced cells. 3. 3. In rats, colchicine 0.3 mg/kg, reduced significantly the allyl-isopropylacetamide induced increase in the activity of delta-aminolevulinic acid synthase in the liver and the concentration of urinary porphyrins while it did not affect these parameters in non-induced rats.

Original languageEnglish
Pages (from-to)937-940
Number of pages4
JournalInternational Journal of Biochemistry
Volume17
Issue number8
DOIs
StatePublished - 1985

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