Inhibition of delayed hypersensitivity reactions by cochicine. II. Colchicine inhibits interferon-gamma induced expression of HLA-DR on gut epithelial cell line

Y. A. Mekori; Y. Chowers; I. Drucker; A. Klajman

Inhibition of delayed hypersensitivity reactions by cochicine. II. Colchicine inhibits interferon-gamma induced expression of HLA-DR on gut epithelial cell line

Y. A. Mekori, Y. Chowers, I. Drucker, A. Klajman^*

^*Corresponding author for this work

Meier Hospital

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The effects of colchicine and vinblastine on interferon-gamma (IFN-γ) induced expression of HLA-DR antigens on the HT-29 colonic carcinoma cell lines was investigated in vitro. Both drugs prevented the expression of HLA-DR only if applied before or together with IFN-γ. Methotrexate, an anti-mitotic drug, failed to inhibit DR expression by these cells. Colchicine and vinblastine, but not methotrexate, act on the cellular microtubules, interfering with the transport of proteins from the protoplasm to the cell surface and thus preventing the appearance of HLA-DR antigens. The reported findings may explain the role of colchicine in preventing delayed hypersensitivity reactions.

Original language	English
Pages (from-to)	230-232
Number of pages	3
Journal	Clinical and Experimental Immunology
Volume	78
Issue number	2
State	Published - 1989
Externally published	Yes

Keywords

Colchicine
HLA-DR antigen
Interferon-gamma

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abstract = "The effects of colchicine and vinblastine on interferon-gamma (IFN-γ) induced expression of HLA-DR antigens on the HT-29 colonic carcinoma cell lines was investigated in vitro. Both drugs prevented the expression of HLA-DR only if applied before or together with IFN-γ. Methotrexate, an anti-mitotic drug, failed to inhibit DR expression by these cells. Colchicine and vinblastine, but not methotrexate, act on the cellular microtubules, interfering with the transport of proteins from the protoplasm to the cell surface and thus preventing the appearance of HLA-DR antigens. The reported findings may explain the role of colchicine in preventing delayed hypersensitivity reactions.",

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AU - Mekori, Y. A.

AU - Chowers, Y.

AU - Drucker, I.

AU - Klajman, A.

PY - 1989

Y1 - 1989

N2 - The effects of colchicine and vinblastine on interferon-gamma (IFN-γ) induced expression of HLA-DR antigens on the HT-29 colonic carcinoma cell lines was investigated in vitro. Both drugs prevented the expression of HLA-DR only if applied before or together with IFN-γ. Methotrexate, an anti-mitotic drug, failed to inhibit DR expression by these cells. Colchicine and vinblastine, but not methotrexate, act on the cellular microtubules, interfering with the transport of proteins from the protoplasm to the cell surface and thus preventing the appearance of HLA-DR antigens. The reported findings may explain the role of colchicine in preventing delayed hypersensitivity reactions.

AB - The effects of colchicine and vinblastine on interferon-gamma (IFN-γ) induced expression of HLA-DR antigens on the HT-29 colonic carcinoma cell lines was investigated in vitro. Both drugs prevented the expression of HLA-DR only if applied before or together with IFN-γ. Methotrexate, an anti-mitotic drug, failed to inhibit DR expression by these cells. Colchicine and vinblastine, but not methotrexate, act on the cellular microtubules, interfering with the transport of proteins from the protoplasm to the cell surface and thus preventing the appearance of HLA-DR antigens. The reported findings may explain the role of colchicine in preventing delayed hypersensitivity reactions.

KW - Colchicine

KW - HLA-DR antigen

KW - Interferon-gamma

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SN - 0009-9104

VL - 78

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JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

IS - 2

ER -

Inhibition of delayed hypersensitivity reactions by cochicine. II. Colchicine inhibits interferon-gamma induced expression of HLA-DR on gut epithelial cell line

Abstract

Keywords

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