TY - JOUR
T1 - Inhibition by ATP of Erythrocyte Glucose-6-Phosphate Dehydrogenase Variants
AU - Ben-Bassat, Isaac
AU - Beutler, Ernest
N1 - Funding Information:
This work was supported, in part, by Grant HL 07449 from the NIH. 2
PY - 1973/2
Y1 - 1973/2
N2 - ATP is a competitive inhibitor of erythrocyte glucose-6-phosphate dehydrogenase. Inhibition of the normal enzyme and the enzyme of six variants, four of them associated with nonspherocytic congenital hemolytic anemia was investigated. None of the variants manifested undue sensitivity to ATP inhibition. It is concluded that inhibition by physiologic levels of ATP is probably not a major factor in the pathogenesis of hemolysis in these variants.
AB - ATP is a competitive inhibitor of erythrocyte glucose-6-phosphate dehydrogenase. Inhibition of the normal enzyme and the enzyme of six variants, four of them associated with nonspherocytic congenital hemolytic anemia was investigated. None of the variants manifested undue sensitivity to ATP inhibition. It is concluded that inhibition by physiologic levels of ATP is probably not a major factor in the pathogenesis of hemolysis in these variants.
UR - http://www.scopus.com/inward/record.url?scp=0015576930&partnerID=8YFLogxK
U2 - 10.3181/00379727-142-37034
DO - 10.3181/00379727-142-37034
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AN - SCOPUS:0015576930
SN - 0037-9727
VL - 142
SP - 410
EP - 411
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
IS - 2
ER -