Inhibition by ATP of Erythrocyte Glucose-6-Phosphate Dehydrogenase Variants

Isaac Ben-Bassat, Ernest Beutler

Research output: Contribution to journalArticlepeer-review

Abstract

ATP is a competitive inhibitor of erythrocyte glucose-6-phosphate dehydrogenase. Inhibition of the normal enzyme and the enzyme of six variants, four of them associated with nonspherocytic congenital hemolytic anemia was investigated. None of the variants manifested undue sensitivity to ATP inhibition. It is concluded that inhibition by physiologic levels of ATP is probably not a major factor in the pathogenesis of hemolysis in these variants.

Original languageEnglish
Pages (from-to)410-411
Number of pages2
JournalExperimental Biology and Medicine
Volume142
Issue number2
DOIs
StatePublished - Feb 1973
Externally publishedYes

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