INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community

Terrence F. Meehan; Chao Kung Chen; Gautier Koscielny; Mike Relac; Phil Wilkinson; Paul Flicek; Helen Parkinson; Joanna Bottomley; Ramiro Ramirez-Solis; Damian Smedley; Ana Castro; Sabine Fessele; Ralph Steinkamp; Michael Hagn; Michael Raess; Martin Hrabé De Angelis; Simon Ball; Andrew Blake; Martin Fray; Janet Kenyon; Ann Marie Mallon; Steve Brown; Marzia Massimi; Raffaele Matteoni; Glauco Tocchini-Valentini; Yann Herault; George Kollias; Brun Ulfhake; Jocelyne Demengeot; Cecile Fremond; Fatima Bosch; Lluis Montoliu; Raija Soininen; Klaus Schughart; Cord Brakebusch; Radislav Sedlacek; Thomas Rülicke; Colin McKerlie; Bernard Malissen; Fuad Iraqi; Jos Jonkers; Holger Russig; Danny Huylebroeck

doi:10.1093/nar/gku1193

INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community

Terrence F. Meehan^*, Chao Kung Chen, Gautier Koscielny, Mike Relac, Phil Wilkinson, Paul Flicek, Helen Parkinson, Joanna Bottomley, Ramiro Ramirez-Solis, Damian Smedley, Ana Castro, Sabine Fessele, Ralph Steinkamp, Michael Hagn, Michael Raess, Martin Hrabé De Angelis, Simon Ball, Andrew Blake, Martin Fray, Janet KenyonAnn Marie Mallon, Steve Brown, Marzia Massimi, Raffaele Matteoni, Glauco Tocchini-Valentini, Yann Herault, George Kollias, Brun Ulfhake, Jocelyne Demengeot, Cecile Fremond, Fatima Bosch, Lluis Montoliu, Raija Soininen, Klaus Schughart, Cord Brakebusch, Radislav Sedlacek, Thomas Rülicke, Colin McKerlie, Bernard Malissen, Fuad Iraqi, Jos Jonkers, Holger Russig, Danny Huylebroeck

^*Corresponding author for this work

Clinical Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The laboratory mouse is a key model organism to investigate mechanism and therapeutics of human disease. The number of targeted genetic mouse models of disease is growing rapidly due to high-throughput production strategies employed by the International Mouse Phenotyping Consortium (IMPC) and the development of new, more efficient genome engineering techniques such as CRISPR based systems. We have previously described the European Mouse Mutant Archive (EMMA) resource and how this international infrastructure provides archiving and distribution worldwide for mutant mouse strains. EMMA has since evolved into INFRAFRONTIER (http://www.infrafrontier.eu), the pan-European research infrastructure for the systemic phenotyping, archiving and distribution of mouse disease models. Here we describe new features including improved search for mouse strains, support for new embryonic stem cell resources, access to training materials via a comprehensive knowledgebase and the promotion of innovative analytical and diagnostic techniques.

Original language	English
Pages (from-to)	D1171-D1175
Journal	Nucleic Acids Research
Volume	43
Issue number	D1
DOIs	https://doi.org/10.1093/nar/gku1193
State	Published - 28 Jan 2015

Funding

Funders	Funder number
Veterinärmedizinische Universität Wien
Institut Clinique de la Souris
CNB-CSIC
European Bioin-formatics Institute
IN-SERM
Institut de Génétique et de Biologie Moléculaire et Cellulaire
Advanced Scientific Computing Research
Centro Nacional de Biotecnologia
Københavns Universitet
CIBER-ER-ISCIII
European Commission
Wellcome Trust
Oulun Yliopisto
Consiglio Nazionale delle Ricerche
Universitat Autònoma de Barcelona
Tel Aviv University
European Molecular Biology Laboratory
Colin McKerlie
Netherlands Cancer Institute
Fatima Bosch
Institute of Laboratory Animal Science and Biomodels Austria
Helmholtz Zentrum für In-fektionsforschung GmbH
Seventh Framework Programme	312325, 284501, 211404
Medical Research Council	MC_U142684172, MC_UP_1502/2

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10.1093/nar/gku1193

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Meehan, T. F., Chen, C. K., Koscielny, G., Relac, M., Wilkinson, P., Flicek, P., Parkinson, H., Bottomley, J., Ramirez-Solis, R., Smedley, D., Castro, A., Fessele, S., Steinkamp, R., Hagn, M., Raess, M., De Angelis, M. H., Ball, S., Blake, A., Fray, M., ... Huylebroeck, D. (2015). INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community. Nucleic Acids Research, 43(D1), D1171-D1175. https://doi.org/10.1093/nar/gku1193

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title = "INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community",

abstract = "The laboratory mouse is a key model organism to investigate mechanism and therapeutics of human disease. The number of targeted genetic mouse models of disease is growing rapidly due to high-throughput production strategies employed by the International Mouse Phenotyping Consortium (IMPC) and the development of new, more efficient genome engineering techniques such as CRISPR based systems. We have previously described the European Mouse Mutant Archive (EMMA) resource and how this international infrastructure provides archiving and distribution worldwide for mutant mouse strains. EMMA has since evolved into INFRAFRONTIER (http://www.infrafrontier.eu), the pan-European research infrastructure for the systemic phenotyping, archiving and distribution of mouse disease models. Here we describe new features including improved search for mouse strains, support for new embryonic stem cell resources, access to training materials via a comprehensive knowledgebase and the promotion of innovative analytical and diagnostic techniques.",

author = "Meehan, {Terrence F.} and Chen, {Chao Kung} and Gautier Koscielny and Mike Relac and Phil Wilkinson and Paul Flicek and Helen Parkinson and Joanna Bottomley and Ramiro Ramirez-Solis and Damian Smedley and Ana Castro and Sabine Fessele and Ralph Steinkamp and Michael Hagn and Michael Raess and {De Angelis}, {Martin Hrab{\'e}} and Simon Ball and Andrew Blake and Martin Fray and Janet Kenyon and Mallon, {Ann Marie} and Steve Brown and Marzia Massimi and Raffaele Matteoni and Glauco Tocchini-Valentini and Yann Herault and George Kollias and Brun Ulfhake and Jocelyne Demengeot and Cecile Fremond and Fatima Bosch and Lluis Montoliu and Raija Soininen and Klaus Schughart and Cord Brakebusch and Radislav Sedlacek and Thomas R{\"u}licke and Colin McKerlie and Bernard Malissen and Fuad Iraqi and Jos Jonkers and Holger Russig and Danny Huylebroeck",

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doi = "10.1093/nar/gku1193",

language = "אנגלית",

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Meehan, TF, Chen, CK, Koscielny, G, Relac, M, Wilkinson, P, Flicek, P, Parkinson, H, Bottomley, J, Ramirez-Solis, R, Smedley, D, Castro, A, Fessele, S, Steinkamp, R, Hagn, M, Raess, M, De Angelis, MH, Ball, S, Blake, A, Fray, M, Kenyon, J, Mallon, AM, Brown, S, Massimi, M, Matteoni, R, Tocchini-Valentini, G, Herault, Y, Kollias, G, Ulfhake, B, Demengeot, J, Fremond, C, Bosch, F, Montoliu, L, Soininen, R, Schughart, K, Brakebusch, C, Sedlacek, R, Rülicke, T, McKerlie, C, Malissen, B, Iraqi, F, Jonkers, J, Russig, H & Huylebroeck, D 2015, 'INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community', Nucleic Acids Research, vol. 43, no. D1, pp. D1171-D1175. https://doi.org/10.1093/nar/gku1193

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AU - Meehan, Terrence F.

AU - Chen, Chao Kung

AU - Koscielny, Gautier

AU - Relac, Mike

AU - Wilkinson, Phil

AU - Flicek, Paul

AU - Parkinson, Helen

AU - Bottomley, Joanna

AU - Ramirez-Solis, Ramiro

AU - Smedley, Damian

AU - Castro, Ana

AU - Fessele, Sabine

AU - Steinkamp, Ralph

AU - Hagn, Michael

AU - Raess, Michael

AU - De Angelis, Martin Hrabé

AU - Ball, Simon

AU - Blake, Andrew

AU - Fray, Martin

AU - Kenyon, Janet

AU - Mallon, Ann Marie

AU - Brown, Steve

AU - Massimi, Marzia

AU - Matteoni, Raffaele

AU - Tocchini-Valentini, Glauco

AU - Herault, Yann

AU - Kollias, George

AU - Ulfhake, Brun

AU - Demengeot, Jocelyne

AU - Fremond, Cecile

AU - Bosch, Fatima

AU - Montoliu, Lluis

AU - Soininen, Raija

AU - Schughart, Klaus

AU - Brakebusch, Cord

AU - Sedlacek, Radislav

AU - Rülicke, Thomas

AU - McKerlie, Colin

AU - Malissen, Bernard

AU - Iraqi, Fuad

AU - Jonkers, Jos

AU - Russig, Holger

AU - Huylebroeck, Danny

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INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community

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