INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community

Terrence F. Meehan*, Chao Kung Chen, Gautier Koscielny, Mike Relac, Phil Wilkinson, Paul Flicek, Helen Parkinson, Joanna Bottomley, Ramiro Ramirez-Solis, Damian Smedley, Ana Castro, Sabine Fessele, Ralph Steinkamp, Michael Hagn, Michael Raess, Martin Hrabé De Angelis, Simon Ball, Andrew Blake, Martin Fray, Janet KenyonAnn Marie Mallon, Steve Brown, Marzia Massimi, Raffaele Matteoni, Glauco Tocchini-Valentini, Yann Herault, George Kollias, Brun Ulfhake, Jocelyne Demengeot, Cecile Fremond, Fatima Bosch, Lluis Montoliu, Raija Soininen, Klaus Schughart, Cord Brakebusch, Radislav Sedlacek, Thomas Rülicke, Colin McKerlie, Bernard Malissen, Fuad Iraqi, Jos Jonkers, Holger Russig, Danny Huylebroeck

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The laboratory mouse is a key model organism to investigate mechanism and therapeutics of human disease. The number of targeted genetic mouse models of disease is growing rapidly due to high-throughput production strategies employed by the International Mouse Phenotyping Consortium (IMPC) and the development of new, more efficient genome engineering techniques such as CRISPR based systems. We have previously described the European Mouse Mutant Archive (EMMA) resource and how this international infrastructure provides archiving and distribution worldwide for mutant mouse strains. EMMA has since evolved into INFRAFRONTIER (, the pan-European research infrastructure for the systemic phenotyping, archiving and distribution of mouse disease models. Here we describe new features including improved search for mouse strains, support for new embryonic stem cell resources, access to training materials via a comprehensive knowledgebase and the promotion of innovative analytical and diagnostic techniques.

Original languageEnglish
Pages (from-to)D1171-D1175
JournalNucleic Acids Research
Issue numberD1
StatePublished - 28 Jan 2015


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