Influenza vaccination of patients with systemic lupus erythematosus: Safety and immunogenecity issues

Mahmoud Abu-Shakra, Joseph Press, Dan Buskila, Shaul Sukenik

Research output: Contribution to journalReview articlepeer-review

Abstract

The influenza vaccine is highly efficacious in the general population; however there have been concerns about the safety, and immunogenecity of the vaccine in patients with SLE. Several studies have suggested that the immune response of patients with SLE to influenza vaccine is significantly lower than the general population, mainly in patients with age ≥ 50 years and those treated with prednisone. The vaccine is safe for patients with SLE and it does not affect the clinical manifestations of SLE including renal features, disease activity, or the requirement for steroids or cytotoxic drugs. However, the vaccine may trigger the generation of autoantibodies which is usually short term and is not associated with clinical significance.

Original languageEnglish
Pages (from-to)543-546
Number of pages4
JournalAutoimmunity Reviews
Volume6
Issue number8
DOIs
StatePublished - Sep 2007
Externally publishedYes

Keywords

  • Autoantibodies
  • Influenza
  • SLE
  • SLEDAI
  • Vaccination

Fingerprint

Dive into the research topics of 'Influenza vaccination of patients with systemic lupus erythematosus: Safety and immunogenecity issues'. Together they form a unique fingerprint.

Cite this