Influence of liver perisinusoidal cell transplantation on liver regeneration after damage induced by CCL4 and 2-acetylaminofluorene

G. R. Burganova; A. A. Titova; E. I. Sharipova; G. O. Pevnev; M. O. Mavlikeev; I. M. Gazizov; A. R. Galyavieva; A. K. Shafigullina; M. S. Kaligin; M. A. Titova; A. A. Gumerova; A. P. Kiassov

Influence of liver perisinusoidal cell transplantation on liver regeneration after damage induced by CCL4 and 2-acetylaminofluorene

G. R. Burganova^*, A. A. Titova, E. I. Sharipova, G. O. Pevnev, M. O. Mavlikeev, I. M. Gazizov, A. R. Galyavieva, A. K. Shafigullina, M. S. Kaligin, M. A. Titova, A. A. Gumerova, A. P. Kiassov

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Research in the past decade allows us to consider liver perisinusoidal cells as a possible regional stem cells of the liver. Despite of this, there is no work dedicated to study their influence to liver regeneration. The aim of this work was to study liver regeneration after liver perisinusoidal cell transplantation in rats with CCL₄ and combination of CCL₄ and 2-acetylaminofluorene damage. Our results showed that in both models of toxic damage transplanted perisinusoidal cells are found in the recipient’s liver and exhibit the properties of stem cells by differentiation into hepatocytes. Transdifferentiation of injected cells into myofibroblasts was not detected which indicates the absence of liver fibrosis risk after use of this cell type for cell therapy.

Original language	English
Pages (from-to)	53-58
Number of pages	6
Journal	Genes and Cells
Volume	9
Issue number	3
State	Published - 2014
Externally published	Yes

Keywords

Carbon tetrachloride
Differentiation
Liver
Liver perisinusoidal cell
Regeneration
Stem cells
Transplantation

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Burganova, G. R., Titova, A. A., Sharipova, E. I., Pevnev, G. O., Mavlikeev, M. O., Gazizov, I. M., Galyavieva, A. R., Shafigullina, A. K., Kaligin, M. S., Titova, M. A., Gumerova, A. A., & Kiassov, A. P. (2014). Influence of liver perisinusoidal cell transplantation on liver regeneration after damage induced by CCL4 and 2-acetylaminofluorene. Genes and Cells, 9(3), 53-58.

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title = "Influence of liver perisinusoidal cell transplantation on liver regeneration after damage induced by CCL4 and 2-acetylaminofluorene",

abstract = "Research in the past decade allows us to consider liver perisinusoidal cells as a possible regional stem cells of the liver. Despite of this, there is no work dedicated to study their influence to liver regeneration. The aim of this work was to study liver regeneration after liver perisinusoidal cell transplantation in rats with CCL4 and combination of CCL4 and 2-acetylaminofluorene damage. Our results showed that in both models of toxic damage transplanted perisinusoidal cells are found in the recipient{\textquoteright}s liver and exhibit the properties of stem cells by differentiation into hepatocytes. Transdifferentiation of injected cells into myofibroblasts was not detected which indicates the absence of liver fibrosis risk after use of this cell type for cell therapy.",

keywords = "Carbon tetrachloride, Differentiation, Liver, Liver perisinusoidal cell, Regeneration, Stem cells, Transplantation",

author = "Burganova, {G. R.} and Titova, {A. A.} and Sharipova, {E. I.} and Pevnev, {G. O.} and Mavlikeev, {M. O.} and Gazizov, {I. M.} and Galyavieva, {A. R.} and Shafigullina, {A. K.} and Kaligin, {M. S.} and Titova, {M. A.} and Gumerova, {A. A.} and Kiassov, {A. P.}",

year = "2014",

language = "אנגלית",

volume = "9",

pages = "53--58",

journal = "Genes and Cells",

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AU - Burganova, G. R.

AU - Titova, A. A.

AU - Sharipova, E. I.

AU - Pevnev, G. O.

AU - Mavlikeev, M. O.

AU - Gazizov, I. M.

AU - Galyavieva, A. R.

AU - Shafigullina, A. K.

AU - Kaligin, M. S.

AU - Titova, M. A.

AU - Gumerova, A. A.

AU - Kiassov, A. P.

PY - 2014

Y1 - 2014

N2 - Research in the past decade allows us to consider liver perisinusoidal cells as a possible regional stem cells of the liver. Despite of this, there is no work dedicated to study their influence to liver regeneration. The aim of this work was to study liver regeneration after liver perisinusoidal cell transplantation in rats with CCL4 and combination of CCL4 and 2-acetylaminofluorene damage. Our results showed that in both models of toxic damage transplanted perisinusoidal cells are found in the recipient’s liver and exhibit the properties of stem cells by differentiation into hepatocytes. Transdifferentiation of injected cells into myofibroblasts was not detected which indicates the absence of liver fibrosis risk after use of this cell type for cell therapy.

AB - Research in the past decade allows us to consider liver perisinusoidal cells as a possible regional stem cells of the liver. Despite of this, there is no work dedicated to study their influence to liver regeneration. The aim of this work was to study liver regeneration after liver perisinusoidal cell transplantation in rats with CCL4 and combination of CCL4 and 2-acetylaminofluorene damage. Our results showed that in both models of toxic damage transplanted perisinusoidal cells are found in the recipient’s liver and exhibit the properties of stem cells by differentiation into hepatocytes. Transdifferentiation of injected cells into myofibroblasts was not detected which indicates the absence of liver fibrosis risk after use of this cell type for cell therapy.

KW - Carbon tetrachloride

KW - Differentiation

KW - Liver

KW - Liver perisinusoidal cell

KW - Regeneration

KW - Stem cells

KW - Transplantation

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SN - 2313-1829

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JO - Genes and Cells

JF - Genes and Cells

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ER -

Influence of liver perisinusoidal cell transplantation on liver regeneration after damage induced by CCL4 and 2-acetylaminofluorene

Abstract

Keywords

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