Influence of GeneXpert MRSA/SA test implementation on clinical outcomes of Staphylococcus aureus bacteremia — a before–after retrospective study

Haim Ben-Zvi, Genady Drozdinsky, Shiri Kushnir, Tomer Avni, Oded Scheuerman, Jihad Bisahra, Dafna Yahav

Research output: Contribution to journalArticlepeer-review

Abstract

Use of GeneXpert MRSA/SA in diagnostic algorithms of Staphylococcus aureus bacteremia may influence both patients’ clinical outcomes and antibiotic stewardship. We evaluated these outcomes in a retrospective cohort before (1/6/2015–31/5/2016) and after (1/6/2016–31/8/2017) the introduction of the test in adult patients with Gram-positive cocci in clusters in blood cultures. We included 254 patients (125 preintervention, 129 postintervention). No significant difference in 30-day mortality or clinical success was demonstrated between periods. Appropriate antibiotic therapy rates were significantly higher in the postintervention group, and vancomycin use was significantly reduced (80.6% vs 53.6%, P < 0.01; 2.3±0.38 vs 2.98±1.02 defined daily doses/100 patient days, P = 0.026, respectively). Appropriate beta-lactam use was also significantly higher (56.7% postintervention vs 23.1% preintervention, P < 0.01). Use of GeneXpert MRSA/SA test has a positive effect on antibiotic stewardship measures, though it has no significant effect on clinical outcomes including mortality in this fatal infection.

Original languageEnglish
Pages (from-to)120-124
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Volume93
Issue number2
DOIs
StatePublished - Feb 2019

Keywords

  • Diagnosis
  • Molecular
  • PCR
  • Staphylococcus aureus bacteremia

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