Influence of body temperature on the epileptogenic effect of enkephalin microinjections into the hippocampus

Z. Elazar*, E. Motles, R. Simantov

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The influence of different body temperatures on the epileptiform discharges induced in hippocampus by local microinjections of leu-enkephalin was studied in rats. In the absence of enkephalin, changes in body temperature by either cooling or heating induced epileptiform discharges that disappeared after temperature stabilization. The epileptiform episode induced by enkephalin microinjections was of longer duration at temperatures below normal (29-30°C). At body temperatures above normal (39-40°C) the epileptiform discharge was less intense and of shorter duration. In vitro testing led to parallel results: the destruction of enkephalin by the brain tissue was faster at higher temperatures. It is proposed that in conditions of hyperthermia enkephalin has a weaker activity due to acceleration of the activity of peptidases involved in its breakdown.

Original languageEnglish
Pages (from-to)640-646
Number of pages7
JournalElectroencephalography and Clinical Neurophysiology
Volume52
Issue number6
DOIs
StatePublished - Dec 1981

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