Inflammatory mediators in inflammatory bowel disease

Iris Dotan*, Daniel Rachmilewitz

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review


Research this year concentrated on defining the role of inflammatory mediators and their modulation in the treatment of inflammatory bowel disease and experimental colitis. Whereas leukotriene B4 blockade was found to have no effect on ulcerative colitis, blockade of thromboxane A2, the inducible nitric oxide synthase, and elimination of oxygen radicals seemed efficacious in animal models. Interest in nitric oxide and oxygen free radicals increased, demonstrating the deleterious effect these molecules have on intestinal inflammation.

Original languageEnglish
Pages (from-to)295-299
Number of pages5
JournalCurrent Opinion in Gastroenterology
Issue number4
StatePublished - 1998
Externally publishedYes


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