Inflammatory bowel disease: Risk factors for adverse pregnancy outcome and the impact of maternal weight gain

Galia Oron, Yariv Yogev*, Smadar Shkolnik, Moshe Hod, Gerald Fraser, Arnon Wiznitzer, Nir Melamed

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Objective: To identify risk factors for adverse pregnancy outcome in women with inflammatory bowel disease (IBD) and to assess the effect of maternal pre-pregnancy weight and weight gain during pregnancy on pregnancy outcome. Methods: A retrospective, matched control study of all gravid women with IBD treated in a single tertiary center. Data were compared with healthy controls matched to by age, parity and pre-pregnancy BMI in a 3:1 ratio. Results: Overall, 300 women were enrolled, 75 women in the study group (28 with ulcerative colitis and 47 with Crohn's disease) and 225 in the control group. The rates of preterm delivery and small for gestational age were higher in the study group (13.3 vs. 5.3% p = 0.02 and 6.7 vs. 0.9%, p = 0.004). The rate of cesarean section (36 vs. 19.1%; p = 0.002), NICU admission (10.7 vs. 4.0%, p = 0.03) and low 5-Min Apgar (4.0 vs. 0.4%, p = 0.02) were increased in the study group. Disease activity within 3 months of conception [OR 8.4 (1.316.3)] and maternal weight gain of less than 12 kg. [OR 3.6 (1.112.2)] were associated with adverse pregnancy outcome. Conclusion: Active disease at conception and inappropriate weight gain during pregnancy are associated with increased adverse pregnancy outcome in patients with IBD.

Original languageEnglish
Pages (from-to)2256-2260
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number11
StatePublished - Nov 2012


  • Complication
  • Inflammatory bowel disease
  • Pregnancy
  • Weight gain


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