Inflammation-sensitive proteins and erythrocyte aggregation in atherothrombosis

Einor Ben Assayag, Nathan Bornstein, Itzhak Shapira, Tamar Mardi, Yelena Goldin, Tatiana Tolshinski, Yafa Vered, Vera Zakuth, Michael Burke, Shlomo Berliner, Dorit Samocha Bonet

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To find the relative contribution of various inflammation-sensitive proteins including fibrinogen, immunoglobulins (IgG, IgM and IgA), ceruloplasmin and high sensitivity C-reactive protein (hs-CRP) to the induction and/or maintenance of enhanced erythrocyte adhesiveness/aggregation in the peripheral blood of individuals with atherothrombotic risk factors. Methods: The degree of erythrocyte adhesiveness/aggregation was determined by a simple slide test and image analysis. In addition, we measured various inflammation-sensitive protein levels including fibrinogen, ceruloplasmin, immunoglobulins and hs-CRP in a group of 234 individuals with atherothrombotic risk factors and healthy ones. Pearson partial correlations and multiple linear regression analysis were performed. Results: Fibrinogen was found to be the major protein contributing to the enhanced erythrocyte adhesiveness/aggregation, explaining 30% of the model. Fibrinogen and IgG together explained 32.4% of the model. Other inflammation-sensitive proteins did not reach statistical significance and were excluded from the model. Conclusions: Among inflammation-sensitive proteins measured in our cohort, fibrinogen is the dominant contributor to erythrocyte adhesiveness/aggregation in the peripheral blood of individuals with atherothrombotic risk factors and healthy ones. These findings may pave the way for the development of therapeutic strategies directed at the attenuation of erythrocyte aggregability in individuals with atherothrombosis.

Original languageEnglish
Pages (from-to)271-276
Number of pages6
JournalInternational Journal of Cardiology
Volume98
Issue number2
DOIs
StatePublished - 15 Feb 2005

Keywords

  • Erythrocyte aggregation
  • Inflammation-sensitive proteins

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