TY - JOUR
T1 - Inflammation, angiogenesis and coagulation interplay in a variety of retinal diseases
AU - Dan-Brezis, Idit
AU - Zahavi, Alon
AU - Axer-Siegel, Ruth
AU - Nisgav, Yael
AU - Dahbash, Mor
AU - Weinberger, Dov
AU - Ehrlich, Rita
AU - Livnat, Tami
N1 - Publisher Copyright:
© 2019 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Purpose: To evaluate and correlate levels of various proteins involved in coagulation, inflammation and angiogenesis processes in the vitreous of patients with different vitreoretinal pathologies. Methods: Vitreous samples were collected from patients scheduled for pars plana vitrectomy for the treatment of rhegmatogenous retinal detachment (RRD), vitreous haemorrhage or tractional retinal detachment associated with proliferative diabetic retinopathy (PDR). Macular hole and epiretinal membrane served as controls. Levels of vascular endothelial growth factor, thrombin–antithrombin III complex, interleukin-8, tissue factor, thrombomodulin, P-selectin, D-dimer and tissue factor pathway inhibitor were compared among the vitreoretinal pathology groups. Results: Compared to controls, patients with PDR had significantly higher levels of thrombin–antithrombin III complex (p < 0.001), vascular endothelial growth factor (p < 0.001), D-dimer (p = 0.038) and interleukin-8 (p = 0.04), and patients with RRD group had significantly higher levels only of thrombin–antithrombin III complex (p < 0.001). There was a significant linear correlation between levels of P-selectin and D-dimer (p = 0.003), P-selectin and interleukin-8 (p < 0.001), and D-dimer and IL-8 (p = 0.007). These correlations were particularly strong in the PDR group compared to the other groups. Conclusion: Patients with PDR manifest high coagulative and angiogenic activity in the vitreous. These pathways are highly correlated with the inflammatory cascade.
AB - Purpose: To evaluate and correlate levels of various proteins involved in coagulation, inflammation and angiogenesis processes in the vitreous of patients with different vitreoretinal pathologies. Methods: Vitreous samples were collected from patients scheduled for pars plana vitrectomy for the treatment of rhegmatogenous retinal detachment (RRD), vitreous haemorrhage or tractional retinal detachment associated with proliferative diabetic retinopathy (PDR). Macular hole and epiretinal membrane served as controls. Levels of vascular endothelial growth factor, thrombin–antithrombin III complex, interleukin-8, tissue factor, thrombomodulin, P-selectin, D-dimer and tissue factor pathway inhibitor were compared among the vitreoretinal pathology groups. Results: Compared to controls, patients with PDR had significantly higher levels of thrombin–antithrombin III complex (p < 0.001), vascular endothelial growth factor (p < 0.001), D-dimer (p = 0.038) and interleukin-8 (p = 0.04), and patients with RRD group had significantly higher levels only of thrombin–antithrombin III complex (p < 0.001). There was a significant linear correlation between levels of P-selectin and D-dimer (p = 0.003), P-selectin and interleukin-8 (p < 0.001), and D-dimer and IL-8 (p = 0.007). These correlations were particularly strong in the PDR group compared to the other groups. Conclusion: Patients with PDR manifest high coagulative and angiogenic activity in the vitreous. These pathways are highly correlated with the inflammatory cascade.
KW - angiogenesis
KW - coagulation
KW - cytokines
KW - proliferative diabetic retinopathy
KW - vitreous
UR - http://www.scopus.com/inward/record.url?scp=85076343003&partnerID=8YFLogxK
U2 - 10.1111/aos.14331
DO - 10.1111/aos.14331
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C2 - 31833198
AN - SCOPUS:85076343003
SN - 1755-375X
VL - 98
SP - e559-e562
JO - Acta Ophthalmologica
JF - Acta Ophthalmologica
IS - 5
ER -