Inflammation, angiogenesis and coagulation interplay in a variety of retinal diseases

Idit Dan-Brezis*, Alon Zahavi, Ruth Axer-Siegel, Yael Nisgav, Mor Dahbash, Dov Weinberger, Rita Ehrlich, Tami Livnat

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Purpose: To evaluate and correlate levels of various proteins involved in coagulation, inflammation and angiogenesis processes in the vitreous of patients with different vitreoretinal pathologies. Methods: Vitreous samples were collected from patients scheduled for pars plana vitrectomy for the treatment of rhegmatogenous retinal detachment (RRD), vitreous haemorrhage or tractional retinal detachment associated with proliferative diabetic retinopathy (PDR). Macular hole and epiretinal membrane served as controls. Levels of vascular endothelial growth factor, thrombin–antithrombin III complex, interleukin-8, tissue factor, thrombomodulin, P-selectin, D-dimer and tissue factor pathway inhibitor were compared among the vitreoretinal pathology groups. Results: Compared to controls, patients with PDR had significantly higher levels of thrombin–antithrombin III complex (p < 0.001), vascular endothelial growth factor (p < 0.001), D-dimer (p = 0.038) and interleukin-8 (p = 0.04), and patients with RRD group had significantly higher levels only of thrombin–antithrombin III complex (p < 0.001). There was a significant linear correlation between levels of P-selectin and D-dimer (p = 0.003), P-selectin and interleukin-8 (p < 0.001), and D-dimer and IL-8 (p = 0.007). These correlations were particularly strong in the PDR group compared to the other groups. Conclusion: Patients with PDR manifest high coagulative and angiogenic activity in the vitreous. These pathways are highly correlated with the inflammatory cascade.

Original languageEnglish
Pages (from-to)e559-e562
JournalActa Ophthalmologica
Issue number5
StatePublished - 1 Aug 2020


  • angiogenesis
  • coagulation
  • cytokines
  • proliferative diabetic retinopathy
  • vitreous


Dive into the research topics of 'Inflammation, angiogenesis and coagulation interplay in a variety of retinal diseases'. Together they form a unique fingerprint.

Cite this