TY - JOUR
T1 - Inflammation and colorectal cancer
T2 - Does aspirin affect the interaction between cancer and immune cells?
AU - Bergman, Michael
AU - Djaldetti, Meir
AU - Salman, Hertzel
AU - Bessler, Hanna
PY - 2011/2
Y1 - 2011/2
N2 - The effect of aspirin on colon-cancer-cell-induced cytokine secretion by peripheral blood mononuclear cells (PBMC) was examined. Aspirin was added to human colon cancer cells (HT-29 and RKO) or to PBMC incubated separately or jointly. The secretion of IFNγ, IL-6, and IL-10 induced by HT-29 cells was decreased, that of IL-1β was slightly increased, whereas IL-1ra production was not affected. With RKO cells, aspirin reduced IL-6, IL-1ra, and IL-10 synthesis and enhanced IFNγ secretion, while IL-1β remained unchanged. Conditioned media from colon cancer cells incubated without or with aspirin stimulated cytokine productions by PBMC similarly, suggesting that aspirin acts on the cell-to-cell interaction between cancer cells and PBMC. The results indicate that aspirin alter the balance between pro- and anti-inflammatory cytokines generated by interaction between colon cancer and immune cells disclosing an additional role of the drug in affecting inflammation-induced colon cancer.
AB - The effect of aspirin on colon-cancer-cell-induced cytokine secretion by peripheral blood mononuclear cells (PBMC) was examined. Aspirin was added to human colon cancer cells (HT-29 and RKO) or to PBMC incubated separately or jointly. The secretion of IFNγ, IL-6, and IL-10 induced by HT-29 cells was decreased, that of IL-1β was slightly increased, whereas IL-1ra production was not affected. With RKO cells, aspirin reduced IL-6, IL-1ra, and IL-10 synthesis and enhanced IFNγ secretion, while IL-1β remained unchanged. Conditioned media from colon cancer cells incubated without or with aspirin stimulated cytokine productions by PBMC similarly, suggesting that aspirin acts on the cell-to-cell interaction between cancer cells and PBMC. The results indicate that aspirin alter the balance between pro- and anti-inflammatory cytokines generated by interaction between colon cancer and immune cells disclosing an additional role of the drug in affecting inflammation-induced colon cancer.
KW - aspirin
KW - cell interaction
KW - colon cancer
KW - cytokines
KW - immunocytes
UR - http://www.scopus.com/inward/record.url?scp=78751646181&partnerID=8YFLogxK
U2 - 10.1007/s10753-010-9203-6
DO - 10.1007/s10753-010-9203-6
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 20349206
AN - SCOPUS:78751646181
SN - 0360-3997
VL - 34
SP - 22
EP - 28
JO - Inflammation
JF - Inflammation
IS - 1
ER -
