Infectious serologies and autoantibodies in hepatitis C and autoimmune disease-associated mixed cryoglobulinemia

Merav Lidar*, Noga Lipschitz, Nancy Agmon-Levin, Pnina Langevitz, Ori Barzilai, Maya Ram, Bat Sheba Porat-Katz, Nicola Bizzaro, Jan Damoiseaux, Jan Willem Cohen Tervaert, Salvatore DeVita, Stefano Bombardieri, Yehuda Shoenfeld

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Mixed cryoglobulinemia (MC) syndrome is an immune complex-mediated vasculitis characterized by the clinical triad of purpura, weakness, and arthralgias, the morbidity of which is mainly related to kidney and peripheral nervous system dysfunction as well as to the development of a secondary lymphoma (Ferri et al. Autoimmun Rev 7:114-120, 2007, Lidar et al. Ann N Y Acad Sci 1173:649-657, 2009, Trejo et al. Semin Arthritis Rheum 33:19-28, 2003). MC is associated with infectious and systemic disorders, principally autoimmune and lymphoproliferative diseases. Since the 1990s, a striking association (90%) between MC and hepatitis C virus (HCV) infection has been established (Ferri and Bombardieri 2004; Pascual et al. J Infect Dis 162:569- 570, 1990). However, information regarding the etiopathogenesis of HCV-negative MC is scant (Mascia et al. Dig Liver Dis 39:61-64, 2007). We hereby present our findings, as well as previously published data, regarding the presence of antibodies against infectious agents and autoantibodies in patients with MC in an attempt to establish novel associations which may shed light on the etiopathogenesis of this disease.

Original languageEnglish
Pages (from-to)238-246
Number of pages9
JournalClinical Reviews in Allergy and Immunology
Volume42
Issue number2
DOIs
StatePublished - Apr 2012

Keywords

  • Autoimmune disease
  • Cryoglobulinemia
  • Cytomegalovirus
  • Epstein-Barr virus
  • H. pylori
  • Hepatitis B
  • Hepatitis C
  • S. mansoni
  • Toxoplasma gondii

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