Infections in Children With Nephrotic Syndrome: Twenty Years of Experience

Asaf Lebel*, Nesia Kropach, Liat Ashkenazi-Hoffnung, Adi Huber-Yaron, Miriam Davidovits

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Infections is a common complication of nephrotic syndrome (NS). Our objective was to evaluate the frequency and risk factors for serious bacterial infections (SBI) in febrile children with NS. We reviewed 239 admissions of 107 children with NS who were admitted with fever to a tertiary hospital in Israel, during 1995 to 2016. SBI was diagnosed in 35 admissions (14.6%), most commonly with pneumonia (n = 12), bacteremia/sepsis (n = 8), and urinary tract infection (n = 6). Patients with SBI were more likely to be female (60.0% vs 36.3%, P =.008) and have nephrotic-range proteinuria (71.4% vs 43.6%, P =.010) and edema (62.9% vs 27.0%, P <.001) on admission. No differences were found between the SBI and non-SBI groups in the clinical and histopathological type of NS, immunosuppressive treatment, rate of pneumococcal vaccination, and prophylactic antibiotics. In summary, 1 of 7 children had SBI, most commonly pneumonia, bacteremia/sepsis, and urinary tract infection. Active nephrosis was associated with an increased risk for SBI.

Original languageEnglish
Pages (from-to)692-698
Number of pages7
JournalClinical Pediatrics
Volume59
Issue number7
DOIs
StatePublished - 1 Jun 2020

Keywords

  • active nephrosis
  • bacteremia
  • nephrotic syndrome
  • pneumonia
  • serious bacterial infections

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