Infections and SLE

Systemic lupus erythematosus (SLE – lupus) is a multi-organ systemic autoimmune disease whose entire mechanism remains an enigma. For decades, lupus patients have been more prone to infections because of the dysfunction of their immune system and if they are treated with very potent immunosuppressive drugs [1]. Infections may occur early in the diagnosis of SLE and/or peak after 5years of disease. Infections may be a trigger to the development or exacerbation of lupus [2]. Furthermore, infections can mimic a flare of lupus, where the appropriate diagnosis and therapy can prevent morbidity and mortality. SLE and infections may be concurrent in 41% of cases. In these patients, an elevated CRP indicates infection [2].