Infection of mice with aerosolized Mycobacterium tuberculosis: Use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility

J. Reid Schwebach; Bing Chen; Aharona Glatman-Freedman; Arturo Casadevall; John D. McKinney; John L. Harb; Patrick J. McGuire; W. Emmett Barkley; Barry R. Bloom; William R. Jacobs

doi:10.1128/AEM.68.9.4646-4649.2002

Infection of mice with aerosolized Mycobacterium tuberculosis: Use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility

J. Reid Schwebach, Bing Chen, Aharona Glatman-Freedman, Arturo Casadevall, John D. McKinney, John L. Harb, Patrick J. McGuire, W. Emmett Barkley, Barry R. Bloom, William R. Jacobs^*

^*Corresponding author for this work

Albert Einstein Coll. Med., 1300 M.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Aerosolized delivery of virulent or hypervirulent Mycobacterium tuberculosis requires careful consideration of methodology and safety. To maximize safety, we installed a nose-only aerosol apparatus that can reproducibly deliver a low dose (<100 CFU per mouse) of M. tuberculosis in a carefully designed biohazard facility.

Original language	English
Pages (from-to)	4646-4649
Number of pages	4
Journal	Applied and Environmental Microbiology
Volume	68
Issue number	9
DOIs	https://doi.org/10.1128/AEM.68.9.4646-4649.2002
State	Published - Sep 2002
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1128/AEM.68.9.4646-4649.2002

Cite this

Schwebach, J. R., Chen, B., Glatman-Freedman, A., Casadevall, A., McKinney, J. D., Harb, J. L., McGuire, P. J., Barkley, W. E., Bloom, B. R., & Jacobs, W. R. (2002). Infection of mice with aerosolized Mycobacterium tuberculosis: Use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility. Applied and Environmental Microbiology, 68(9), 4646-4649. https://doi.org/10.1128/AEM.68.9.4646-4649.2002

@article{9d0bab77bd104f879ca06220293bf2df,

title = "Infection of mice with aerosolized Mycobacterium tuberculosis: Use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility",

abstract = "Aerosolized delivery of virulent or hypervirulent Mycobacterium tuberculosis requires careful consideration of methodology and safety. To maximize safety, we installed a nose-only aerosol apparatus that can reproducibly deliver a low dose (<100 CFU per mouse) of M. tuberculosis in a carefully designed biohazard facility.",

author = "Schwebach, {J. Reid} and Bing Chen and Aharona Glatman-Freedman and Arturo Casadevall and McKinney, {John D.} and Harb, {John L.} and McGuire, {Patrick J.} and Barkley, {W. Emmett} and Bloom, {Barry R.} and Jacobs, {William R.}",

year = "2002",

month = sep,

doi = "10.1128/AEM.68.9.4646-4649.2002",

language = "אנגלית",

volume = "68",

pages = "4646--4649",

journal = "Applied and Environmental Microbiology",

issn = "0099-2240",

publisher = "American Society for Microbiology",

number = "9",

}

Schwebach, JR, Chen, B, Glatman-Freedman, A, Casadevall, A, McKinney, JD, Harb, JL, McGuire, PJ, Barkley, WE, Bloom, BR & Jacobs, WR 2002, 'Infection of mice with aerosolized Mycobacterium tuberculosis: Use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility', Applied and Environmental Microbiology, vol. 68, no. 9, pp. 4646-4649. https://doi.org/10.1128/AEM.68.9.4646-4649.2002

Infection of mice with aerosolized Mycobacterium tuberculosis: Use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility. / Schwebach, J. Reid; Chen, Bing; Glatman-Freedman, Aharona et al.
In: Applied and Environmental Microbiology, Vol. 68, No. 9, 09.2002, p. 4646-4649.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Infection of mice with aerosolized Mycobacterium tuberculosis

T2 - Use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility

AU - Schwebach, J. Reid

AU - Chen, Bing

AU - Glatman-Freedman, Aharona

AU - Casadevall, Arturo

AU - McKinney, John D.

AU - Harb, John L.

AU - McGuire, Patrick J.

AU - Barkley, W. Emmett

AU - Bloom, Barry R.

AU - Jacobs, William R.

PY - 2002/9

Y1 - 2002/9

N2 - Aerosolized delivery of virulent or hypervirulent Mycobacterium tuberculosis requires careful consideration of methodology and safety. To maximize safety, we installed a nose-only aerosol apparatus that can reproducibly deliver a low dose (<100 CFU per mouse) of M. tuberculosis in a carefully designed biohazard facility.

AB - Aerosolized delivery of virulent or hypervirulent Mycobacterium tuberculosis requires careful consideration of methodology and safety. To maximize safety, we installed a nose-only aerosol apparatus that can reproducibly deliver a low dose (<100 CFU per mouse) of M. tuberculosis in a carefully designed biohazard facility.

UR - http://www.scopus.com/inward/record.url?scp=0036727247&partnerID=8YFLogxK

U2 - 10.1128/AEM.68.9.4646-4649.2002

DO - 10.1128/AEM.68.9.4646-4649.2002

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 12200325

AN - SCOPUS:0036727247

SN - 0099-2240

VL - 68

SP - 4646

EP - 4649

JO - Applied and Environmental Microbiology

JF - Applied and Environmental Microbiology

IS - 9

ER -

Infection of mice with aerosolized Mycobacterium tuberculosis: Use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this