Infection of human fetal dorsal root neurons with wild type varicella virus and the Oka strain varicella vaccine

Eli Somekh, Myron J. Levin

Research output: Contribution to journalArticlepeer-review

Abstract

The relative ability of a varicella‐zoster virus (VZV) clinical isolate and a live attenuated VZV vaccine strain (Oka) to infect human neurons was determined in vitro. VZV infection of neurons prepared in culture from dorsal root ganglia of fetuses was assessed using an infectious center assay. Cultures were infected with 50–5,000 pfu of either VZV and assayed at either 24 or 48 hours post‐VZV infection. Cultures infected with the clinical VZV isolate had seven‐fold more infected neurons than cultures infected with the vaccine strain VZV. © 1993 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)241-243
Number of pages3
JournalJournal of Medical Virology
Volume40
Issue number3
DOIs
StatePublished - Jul 1993
Externally publishedYes

Keywords

  • human fetal dorsal root neurons
  • varicella vaccine
  • varicella‐zoster virus

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