TY - JOUR
T1 - Infection of human fetal dorsal root neurons with wild type varicella virus and the Oka strain varicella vaccine
AU - Somekh, Eli
AU - Levin, Myron J.
PY - 1993/7
Y1 - 1993/7
N2 - The relative ability of a varicella‐zoster virus (VZV) clinical isolate and a live attenuated VZV vaccine strain (Oka) to infect human neurons was determined in vitro. VZV infection of neurons prepared in culture from dorsal root ganglia of fetuses was assessed using an infectious center assay. Cultures were infected with 50–5,000 pfu of either VZV and assayed at either 24 or 48 hours post‐VZV infection. Cultures infected with the clinical VZV isolate had seven‐fold more infected neurons than cultures infected with the vaccine strain VZV. © 1993 Wiley‐Liss, Inc.
AB - The relative ability of a varicella‐zoster virus (VZV) clinical isolate and a live attenuated VZV vaccine strain (Oka) to infect human neurons was determined in vitro. VZV infection of neurons prepared in culture from dorsal root ganglia of fetuses was assessed using an infectious center assay. Cultures were infected with 50–5,000 pfu of either VZV and assayed at either 24 or 48 hours post‐VZV infection. Cultures infected with the clinical VZV isolate had seven‐fold more infected neurons than cultures infected with the vaccine strain VZV. © 1993 Wiley‐Liss, Inc.
KW - human fetal dorsal root neurons
KW - varicella vaccine
KW - varicella‐zoster virus
UR - http://www.scopus.com/inward/record.url?scp=0027160703&partnerID=8YFLogxK
U2 - 10.1002/jmv.1890400313
DO - 10.1002/jmv.1890400313
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C2 - 8394874
AN - SCOPUS:0027160703
VL - 40
SP - 241
EP - 243
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 0146-6615
IS - 3
ER -
