Induction of tolerance to an IgG autoantibody

D. Offen*, L. Spatz, H. Escowitz, S. Factor, B. Diamond

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Nonautoimmune mice transgenic for the heavy chain of an IgG2b anti-double- stranded-DNA antibody express the transgene in lymphoid organs and display partial allelic exclusion of this γ2b transgene. The spleens of these mice are characterized by marked B-cell depletion. Although there are B cells in these mice that express the transgene and recognize double-stranded DNA, they are anergic in vivo. Recovery from the state of anergy occurs in vitro after lipopolysaccharide stimulation. Thus this transgenic model demonstrates the induction of self tolerance to an IgG autoantibody.

Original languageEnglish
Pages (from-to)8332-8336
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume89
Issue number17
DOIs
StatePublished - 1992

Keywords

  • allelic exclusion
  • anergy
  • B-cell tolerance
  • double-stranded DNA antibody

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