Induction of hippocampal neurogenesis by a tolerogenic peptide that ameliorates lupus manifestations

Alona Telerman; Smadar Lapter; Amir Sharabi; Heidy Zinger; Edna Mozes

doi:10.1016/j.jneuroim.2010.11.001

Induction of hippocampal neurogenesis by a tolerogenic peptide that ameliorates lupus manifestations

Alona Telerman, Smadar Lapter, Amir Sharabi, Heidy Zinger, Edna Mozes^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

To determine the effect of the tolerogenic peptide hCDR1 on hippocampal neurogenesis, we treated SLE-afflicted (NZBxNZW)F1 mice with hCDR1 (once a week for 10. weeks). The treatment resulted in the up-regulation of neurogenesis in the dentate gyrus and restored the NeuN immunoreactivity in brain hippocampi of the mice in association with increased gene expression of IGF-1, NGF and BDNF. Furthermore, hCDR1 treatment significantly up-regulated p-ERK and p-Akt that are suggested to be key components in mediating growth factor-induced neurogenesis. The observed effects of hCDR1 on hippocampal-neurogenesis and on associated signaling pathways suggest a potential role for hCDR1 in CNS lupus.

Original language	English
Pages (from-to)	151-157
Number of pages	7
Journal	Journal of Neuroimmunology
Volume	232
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2010.11.001
State	Published - Mar 2011
Externally published	Yes

Keywords

A model of systemic lupus erythematosus
A tolerogenic peptide
ERK and Akt pathways
Growth and neurotrophic factors
Hippocampal neurogenesis

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10.1016/j.jneuroim.2010.11.001

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title = "Induction of hippocampal neurogenesis by a tolerogenic peptide that ameliorates lupus manifestations",

abstract = "To determine the effect of the tolerogenic peptide hCDR1 on hippocampal neurogenesis, we treated SLE-afflicted (NZBxNZW)F1 mice with hCDR1 (once a week for 10. weeks). The treatment resulted in the up-regulation of neurogenesis in the dentate gyrus and restored the NeuN immunoreactivity in brain hippocampi of the mice in association with increased gene expression of IGF-1, NGF and BDNF. Furthermore, hCDR1 treatment significantly up-regulated p-ERK and p-Akt that are suggested to be key components in mediating growth factor-induced neurogenesis. The observed effects of hCDR1 on hippocampal-neurogenesis and on associated signaling pathways suggest a potential role for hCDR1 in CNS lupus.",

keywords = "A model of systemic lupus erythematosus, A tolerogenic peptide, ERK and Akt pathways, Growth and neurotrophic factors, Hippocampal neurogenesis",

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AU - Lapter, Smadar

AU - Sharabi, Amir

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AU - Mozes, Edna

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Induction of hippocampal neurogenesis by a tolerogenic peptide that ameliorates lupus manifestations

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