Induction of hippocampal neurogenesis by a tolerogenic peptide that ameliorates lupus manifestations

Alona Telerman, Smadar Lapter, Amir Sharabi, Heidy Zinger, Edna Mozes*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

To determine the effect of the tolerogenic peptide hCDR1 on hippocampal neurogenesis, we treated SLE-afflicted (NZBxNZW)F1 mice with hCDR1 (once a week for 10. weeks). The treatment resulted in the up-regulation of neurogenesis in the dentate gyrus and restored the NeuN immunoreactivity in brain hippocampi of the mice in association with increased gene expression of IGF-1, NGF and BDNF. Furthermore, hCDR1 treatment significantly up-regulated p-ERK and p-Akt that are suggested to be key components in mediating growth factor-induced neurogenesis. The observed effects of hCDR1 on hippocampal-neurogenesis and on associated signaling pathways suggest a potential role for hCDR1 in CNS lupus.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalJournal of Neuroimmunology
Volume232
Issue number1-2
DOIs
StatePublished - Mar 2011
Externally publishedYes

Keywords

  • A model of systemic lupus erythematosus
  • A tolerogenic peptide
  • ERK and Akt pathways
  • Growth and neurotrophic factors
  • Hippocampal neurogenesis

Fingerprint

Dive into the research topics of 'Induction of hippocampal neurogenesis by a tolerogenic peptide that ameliorates lupus manifestations'. Together they form a unique fingerprint.

Cite this