TY - JOUR
T1 - Induction of hippocampal neurogenesis by a tolerogenic peptide that ameliorates lupus manifestations
AU - Telerman, Alona
AU - Lapter, Smadar
AU - Sharabi, Amir
AU - Zinger, Heidy
AU - Mozes, Edna
PY - 2011/3
Y1 - 2011/3
N2 - To determine the effect of the tolerogenic peptide hCDR1 on hippocampal neurogenesis, we treated SLE-afflicted (NZBxNZW)F1 mice with hCDR1 (once a week for 10. weeks). The treatment resulted in the up-regulation of neurogenesis in the dentate gyrus and restored the NeuN immunoreactivity in brain hippocampi of the mice in association with increased gene expression of IGF-1, NGF and BDNF. Furthermore, hCDR1 treatment significantly up-regulated p-ERK and p-Akt that are suggested to be key components in mediating growth factor-induced neurogenesis. The observed effects of hCDR1 on hippocampal-neurogenesis and on associated signaling pathways suggest a potential role for hCDR1 in CNS lupus.
AB - To determine the effect of the tolerogenic peptide hCDR1 on hippocampal neurogenesis, we treated SLE-afflicted (NZBxNZW)F1 mice with hCDR1 (once a week for 10. weeks). The treatment resulted in the up-regulation of neurogenesis in the dentate gyrus and restored the NeuN immunoreactivity in brain hippocampi of the mice in association with increased gene expression of IGF-1, NGF and BDNF. Furthermore, hCDR1 treatment significantly up-regulated p-ERK and p-Akt that are suggested to be key components in mediating growth factor-induced neurogenesis. The observed effects of hCDR1 on hippocampal-neurogenesis and on associated signaling pathways suggest a potential role for hCDR1 in CNS lupus.
KW - A model of systemic lupus erythematosus
KW - A tolerogenic peptide
KW - ERK and Akt pathways
KW - Growth and neurotrophic factors
KW - Hippocampal neurogenesis
UR - http://www.scopus.com/inward/record.url?scp=79952248042&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2010.11.001
DO - 10.1016/j.jneuroim.2010.11.001
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C2 - 21129786
AN - SCOPUS:79952248042
SN - 0165-5728
VL - 232
SP - 151
EP - 157
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -