TY - JOUR
T1 - Induction of depression with oxotremorine in patients with Alzheimer's disease
AU - Davis, K. L.
AU - Hollander, E.
AU - Davidson, M.
AU - Mohs, R. C.
AU - Horvath, T. B.
PY - 1987
Y1 - 1987
N2 - Cholinergic neurotransmission has long been implicated in the development of depression. In this study seven patients with Alzheimer's disease were given oral oxotremorine, a long-acting cholinergic agonist, to assess the drug's effect on cognitive function. There were unexpected depressive reactions in five of the seven patients; three patients dropped out of the study because of these side effects. Cardiovascular effects of the drug were negligible, but its effect on memory and cognition remains unknown because of the small number of subjects who completed the study.
AB - Cholinergic neurotransmission has long been implicated in the development of depression. In this study seven patients with Alzheimer's disease were given oral oxotremorine, a long-acting cholinergic agonist, to assess the drug's effect on cognitive function. There were unexpected depressive reactions in five of the seven patients; three patients dropped out of the study because of these side effects. Cardiovascular effects of the drug were negligible, but its effect on memory and cognition remains unknown because of the small number of subjects who completed the study.
UR - http://www.scopus.com/inward/record.url?scp=0023177967&partnerID=8YFLogxK
U2 - 10.1176/ajp.144.4.468
DO - 10.1176/ajp.144.4.468
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C2 - 3565616
AN - SCOPUS:0023177967
VL - 144
SP - 468
EP - 471
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
SN - 0002-953X
IS - 4
ER -
