Induction of depression with oxotremorine in patients with Alzheimer's disease

K. L. Davis, E. Hollander, M. Davidson, R. C. Mohs, T. B. Horvath

Research output: Contribution to journalArticlepeer-review


Cholinergic neurotransmission has long been implicated in the development of depression. In this study seven patients with Alzheimer's disease were given oral oxotremorine, a long-acting cholinergic agonist, to assess the drug's effect on cognitive function. There were unexpected depressive reactions in five of the seven patients; three patients dropped out of the study because of these side effects. Cardiovascular effects of the drug were negligible, but its effect on memory and cognition remains unknown because of the small number of subjects who completed the study.

Original languageEnglish
Pages (from-to)468-471
Number of pages4
JournalAmerican Journal of Psychiatry
Issue number4
StatePublished - 1987
Externally publishedYes


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