Induction of complement factor B activity in human fibroblasts by IL-6/IFN-β2 and IFN-γ

I. Barash, Z. Fishelson, M. Revel

Research output: Contribution to journalArticlepeer-review

Abstract

Human skin fibroblasts sythesize and secrete complement Factor B, a component of the complement alternative pathway, when stimulated by mediators of inflammation such as lipopolysaccharide and various cytokines. Recombinant IL-6/IFN-β2 (E. coli) stimulates Factor B synthesis in fibroblasts but the effect is strongly potentiated by the addition of IFN-γ. When both cytokines are added, the skin fibroblasts secrete significant amounts of biologically active Factor B detectabel in a hemolysis test. This cooperative effect of IL-6, which is made by most tissue cells and monocytes and of IFN-γ which is made by T-lymphocytes may play a role in local inflammatory processes. IL-6 and IFN-γ also cooperate in the induction of (2'-5') A synthetase, a mediator of IFN action.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalJournal of Biological Regulators and Homeostatic Agents
Volume3
Issue number4
StatePublished - 1989
Externally publishedYes

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