Induction of artificial endometrial cycles with s.c. oestrogen implants and injectable progesterone in in-vitro fertilization treatment with donated oocytes: A preliminary report

I. Ben-Nun, A. Shulman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Endometrial preparation for embryo implantation in oocyte recipients with retained ovarian function presents a special problem. In all, 10 women with preserved ovarian function received donated oocytes in an in-vitro fertilization programme. In the preparatory cycles with oral oestrogens, all failed to develop adequate secretory endometrium because of ill-timed early luteinization occurring during the proliferative phase of the cycle. Subsequently the patients were treated with s.c. 17-β oestradiol implants and injectable progesterone. The implants successfully induced complete down-regulation of the hypothalamus, pituitary axis, and prevented luteinizing hormone (LH) surge. In these preparatory cycles, all the treated patients produced adequate secretory endometrium. Clinical trials of 27 oocyte donation cycles yielded one biochemical and eight clinical pregancies.

Original languageEnglish
Pages (from-to)2267-2270
Number of pages4
JournalHuman Reproduction
Volume12
Issue number10
DOIs
StatePublished - 1997
Externally publishedYes

Keywords

  • In-vitro fertilization
  • Oestrogen implants
  • Oestrogen replacement
  • Oocyte donation

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