Induction of allospecific suppressor T Cells in vitro

Avi Eisenthal*, David Nachtigal, Michael Feldman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Incubation of mouse thymic lymphocytes with irradiated allogeneic spleen cells gave rise to suppressor cells. The suppressor activity was assayed by adding the incubated cell mixture to a mixed lymphocyte culture (MLC) in which the responder cells were syngeneic with the sensitized thymocytes and the stimulator cells were syngeneic with the sensitizing spleen cells. Such addition suppressed significantly thymidine incorporation in the mixed lymphocyte reaction (MLR). The suppressor cells were found to carry the θ antigen and to function allospecifically, as shown by cross-testing in three allogeneic combinations. Our data suggest that these cells may originate from immature cortisone-sensitive thymic lymphocytes and also provide some preliminary information concerning their mode of action.

Original languageEnglish
Pages (from-to)112-124
Number of pages13
JournalCellular Immunology
Issue number1
StatePublished - Nov 1977
Externally publishedYes


FundersFunder number
Thyssen Foundation


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