Induction chemotherapy for locally advanced laryngeal and hypopharyngeal cancer: Single institution experience

Or Dagan; Assaf Moore; Yuval Nachalon; Uri Alkan; Ameen Biadsee; Isaac Shochat; Aron Popovtzer

doi:10.1002/hed.26353

Induction chemotherapy for locally advanced laryngeal and hypopharyngeal cancer: Single institution experience

Or Dagan, Assaf Moore, Yuval Nachalon, Uri Alkan, Ameen Biadsee, Isaac Shochat, Aron Popovtzer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background: The role of induction chemotherapy (IC) in locally-advanced head and neck squamous cell carcinoma (LAHNSCC) is unclear. Methods: A retrospective study of 104 patients with LAHNSCC of the larynx and hypopharynx, treated with IC or up-front chemoradiotherapy (CRT). Results: Eighty patients received CRT and 24 IC followed by CRT; median follow up was 51.33 months. IC significantly improved median overall survival (OS) in the hypopharyngeal cancer group (64.7 vs 21 months, P =.003); with significant difference in the proportion of complete response at first imaging assessment post definitive CRT; no significant difference in disease free survival (DFS), loco-regional or distant failure in the hypopharyngeal cancer group; or OS and DFS in the laryngeal cancer group. Patients with laryngeal cancer had significantly better median OS than those with hypopharyngeal cancer. Conclusions: IC significantly improved complete response rates after CRT, and improved outcomes for patients with locally advanced hypopharyngeal, not laryngeal, cancers.

Original language	English
Pages (from-to)	3118-3124
Number of pages	7
Journal	Head and Neck
Volume	42
Issue number	11
DOIs	https://doi.org/10.1002/hed.26353
State	Published - 1 Nov 2020

Keywords

hypopharyngeal cancer
induction chemotherapy

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title = "Induction chemotherapy for locally advanced laryngeal and hypopharyngeal cancer: Single institution experience",

abstract = "Background: The role of induction chemotherapy (IC) in locally-advanced head and neck squamous cell carcinoma (LAHNSCC) is unclear. Methods: A retrospective study of 104 patients with LAHNSCC of the larynx and hypopharynx, treated with IC or up-front chemoradiotherapy (CRT). Results: Eighty patients received CRT and 24 IC followed by CRT; median follow up was 51.33 months. IC significantly improved median overall survival (OS) in the hypopharyngeal cancer group (64.7 vs 21 months, P =.003); with significant difference in the proportion of complete response at first imaging assessment post definitive CRT; no significant difference in disease free survival (DFS), loco-regional or distant failure in the hypopharyngeal cancer group; or OS and DFS in the laryngeal cancer group. Patients with laryngeal cancer had significantly better median OS than those with hypopharyngeal cancer. Conclusions: IC significantly improved complete response rates after CRT, and improved outcomes for patients with locally advanced hypopharyngeal, not laryngeal, cancers.",

keywords = "hypopharyngeal cancer, induction chemotherapy",

author = "Or Dagan and Assaf Moore and Yuval Nachalon and Uri Alkan and Ameen Biadsee and Isaac Shochat and Aron Popovtzer",

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doi = "10.1002/hed.26353",

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T1 - Induction chemotherapy for locally advanced laryngeal and hypopharyngeal cancer

T2 - Single institution experience

AU - Dagan, Or

AU - Moore, Assaf

AU - Nachalon, Yuval

AU - Alkan, Uri

AU - Biadsee, Ameen

AU - Shochat, Isaac

AU - Popovtzer, Aron

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Background: The role of induction chemotherapy (IC) in locally-advanced head and neck squamous cell carcinoma (LAHNSCC) is unclear. Methods: A retrospective study of 104 patients with LAHNSCC of the larynx and hypopharynx, treated with IC or up-front chemoradiotherapy (CRT). Results: Eighty patients received CRT and 24 IC followed by CRT; median follow up was 51.33 months. IC significantly improved median overall survival (OS) in the hypopharyngeal cancer group (64.7 vs 21 months, P =.003); with significant difference in the proportion of complete response at first imaging assessment post definitive CRT; no significant difference in disease free survival (DFS), loco-regional or distant failure in the hypopharyngeal cancer group; or OS and DFS in the laryngeal cancer group. Patients with laryngeal cancer had significantly better median OS than those with hypopharyngeal cancer. Conclusions: IC significantly improved complete response rates after CRT, and improved outcomes for patients with locally advanced hypopharyngeal, not laryngeal, cancers.

AB - Background: The role of induction chemotherapy (IC) in locally-advanced head and neck squamous cell carcinoma (LAHNSCC) is unclear. Methods: A retrospective study of 104 patients with LAHNSCC of the larynx and hypopharynx, treated with IC or up-front chemoradiotherapy (CRT). Results: Eighty patients received CRT and 24 IC followed by CRT; median follow up was 51.33 months. IC significantly improved median overall survival (OS) in the hypopharyngeal cancer group (64.7 vs 21 months, P =.003); with significant difference in the proportion of complete response at first imaging assessment post definitive CRT; no significant difference in disease free survival (DFS), loco-regional or distant failure in the hypopharyngeal cancer group; or OS and DFS in the laryngeal cancer group. Patients with laryngeal cancer had significantly better median OS than those with hypopharyngeal cancer. Conclusions: IC significantly improved complete response rates after CRT, and improved outcomes for patients with locally advanced hypopharyngeal, not laryngeal, cancers.

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KW - induction chemotherapy

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Induction chemotherapy for locally advanced laryngeal and hypopharyngeal cancer: Single institution experience

Abstract

Keywords

UN SDGs

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