Indications for the role of the immune system in the pathogenesis of corneal alkali burns

Yitshak Ben Hanan; Nahum Landshman; Isaac Avni; Abraham Karsik; Michael Belkin

doi:10.1136/bjo.67.9.635

Indications for the role of the immune system in the pathogenesis of corneal alkali burns

Yitshak Ben Hanan, Nahum Landshman, Isaac Avni, Abraham Karsik, Michael Belkin^*

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We produced alkali burns (1-5 N NaOH) in the right eyes of 63 mice. Three weeks later the left eye of each mouse was similarly burned. All eyes were followed up weekly for 4 weeks after the burn and were graded according to the severity of the lesion. The lesions developed much faster and were more severe in the left eyes. These results suggest that the body's immune mechanism participates in the pathogenesis of alkali corneal burns and adversely affects the development of this condition.

Original language	English
Pages (from-to)	635-637
Number of pages	3
Journal	British Journal of Ophthalmology
Volume	67
Issue number	9
DOIs	https://doi.org/10.1136/bjo.67.9.635
State	Published - 1983

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abstract = "We produced alkali burns (1-5 N NaOH) in the right eyes of 63 mice. Three weeks later the left eye of each mouse was similarly burned. All eyes were followed up weekly for 4 weeks after the burn and were graded according to the severity of the lesion. The lesions developed much faster and were more severe in the left eyes. These results suggest that the body's immune mechanism participates in the pathogenesis of alkali corneal burns and adversely affects the development of this condition.",

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AU - Avni, Isaac

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AU - Belkin, Michael

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N2 - We produced alkali burns (1-5 N NaOH) in the right eyes of 63 mice. Three weeks later the left eye of each mouse was similarly burned. All eyes were followed up weekly for 4 weeks after the burn and were graded according to the severity of the lesion. The lesions developed much faster and were more severe in the left eyes. These results suggest that the body's immune mechanism participates in the pathogenesis of alkali corneal burns and adversely affects the development of this condition.

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Indications for the role of the immune system in the pathogenesis of corneal alkali burns

Abstract

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