Increased xanthine oxidase during labour - Implications for oxidative stress

A. Many; J. M. Roberts

doi:10.1016/S0143-4004(97)90015-1

Increased xanthine oxidase during labour - Implications for oxidative stress

A. Many^*, J. M. Roberts

^*Corresponding author for this work

University of Pittsburgh

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Xanthine dehydrogenase/oxidase (XDH/XO) produces uric acid. When in the oxidase form, this production is coupled with the generation of free radicals. Hypoxia-reperfusion enhances conversion of XDH to XO. Since the placenta is exposed to short periods of hypoxia reperfusion during labour, 17 placentae of pregnancy terminated by elective caesarean section and five placentae of pregnancies terminated by caesarean section during labour were examined for XDH/XO activity. It was found that XO activity was higher in the placentae of labouring women (P = 0.003), which suggests that labour enhances conversion of XDH to XO, facilitating free radical production.

Original language	English
Pages (from-to)	725-726
Number of pages	2
Journal	Placenta
Volume	18
Issue number	8
DOIs	https://doi.org/10.1016/S0143-4004(97)90015-1
State	Published - Nov 1997
Externally published	Yes

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title = "Increased xanthine oxidase during labour - Implications for oxidative stress",

abstract = "Xanthine dehydrogenase/oxidase (XDH/XO) produces uric acid. When in the oxidase form, this production is coupled with the generation of free radicals. Hypoxia-reperfusion enhances conversion of XDH to XO. Since the placenta is exposed to short periods of hypoxia reperfusion during labour, 17 placentae of pregnancy terminated by elective caesarean section and five placentae of pregnancies terminated by caesarean section during labour were examined for XDH/XO activity. It was found that XO activity was higher in the placentae of labouring women (P = 0.003), which suggests that labour enhances conversion of XDH to XO, facilitating free radical production.",

author = "A. Many and Roberts, {J. M.}",

note = "Funding Information: We gratefully acknowledge the help of the Clinical Data Core and the nursing staff{\textquoteleft} of the Magee-Womens Hospital, Pittsburgh, for invaluable assistance in sample collection. We also thank MS Marsha Gallaher for her expert technical assistance. This work was supported by NIHPOl HD30367 and the Irene McClenahan Young Investigator Award Fmd of Magee-Womens Health Foundation.",

year = "1997",

month = nov,

doi = "10.1016/S0143-4004(97)90015-1",

language = "אנגלית",

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journal = "Placenta",

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AU - Roberts, J. M.

N1 - Funding Information: We gratefully acknowledge the help of the Clinical Data Core and the nursing staff‘ of the Magee-Womens Hospital, Pittsburgh, for invaluable assistance in sample collection. We also thank MS Marsha Gallaher for her expert technical assistance. This work was supported by NIHPOl HD30367 and the Irene McClenahan Young Investigator Award Fmd of Magee-Womens Health Foundation.

PY - 1997/11

Y1 - 1997/11

N2 - Xanthine dehydrogenase/oxidase (XDH/XO) produces uric acid. When in the oxidase form, this production is coupled with the generation of free radicals. Hypoxia-reperfusion enhances conversion of XDH to XO. Since the placenta is exposed to short periods of hypoxia reperfusion during labour, 17 placentae of pregnancy terminated by elective caesarean section and five placentae of pregnancies terminated by caesarean section during labour were examined for XDH/XO activity. It was found that XO activity was higher in the placentae of labouring women (P = 0.003), which suggests that labour enhances conversion of XDH to XO, facilitating free radical production.

AB - Xanthine dehydrogenase/oxidase (XDH/XO) produces uric acid. When in the oxidase form, this production is coupled with the generation of free radicals. Hypoxia-reperfusion enhances conversion of XDH to XO. Since the placenta is exposed to short periods of hypoxia reperfusion during labour, 17 placentae of pregnancy terminated by elective caesarean section and five placentae of pregnancies terminated by caesarean section during labour were examined for XDH/XO activity. It was found that XO activity was higher in the placentae of labouring women (P = 0.003), which suggests that labour enhances conversion of XDH to XO, facilitating free radical production.

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Increased xanthine oxidase during labour - Implications for oxidative stress

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