Increased uptake and desulphaton of heparin by mouse macrophages in the presence of polycations

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Abstract

Heparin uptake and desulphation by cultured macrophages were investigated. Histones, polyamino-acids, protamine and eosinophil-basic protein stimulated both heparin uptake and desulphation, processes found to be non-related. Poly-l-ornithine and poly-dl-lysine increased the heparin uptake by about 33-fold, and histone produced up to 7.5-fold increase in the desulphation. The same polycations inhibited heparin desulphation by macrophage extracts.

Original languageEnglish
Pages (from-to)69-76
Number of pages8
JournalBiochimica et Biophysica Acta - General Subjects
Volume544
Issue number1
DOIs
StatePublished - 15 Nov 1978

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