Abstract
Heparin uptake and desulphation by cultured macrophages were investigated. Histones, polyamino-acids, protamine and eosinophil-basic protein stimulated both heparin uptake and desulphation, processes found to be non-related. Poly-l-ornithine and poly-dl-lysine increased the heparin uptake by about 33-fold, and histone produced up to 7.5-fold increase in the desulphation. The same polycations inhibited heparin desulphation by macrophage extracts.
Original language | English |
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Pages (from-to) | 69-76 |
Number of pages | 8 |
Journal | Biochimica et Biophysica Acta - General Subjects |
Volume | 544 |
Issue number | 1 |
DOIs | |
State | Published - 15 Nov 1978 |