TY - JOUR
T1 - Increased uptake and desulphaton of heparin by mouse macrophages in the presence of polycations
AU - Fabian, Ina
AU - Bleiberg, Ilan
AU - Aronson, Moshe
PY - 1978/11/15
Y1 - 1978/11/15
N2 - Heparin uptake and desulphation by cultured macrophages were investigated. Histones, polyamino-acids, protamine and eosinophil-basic protein stimulated both heparin uptake and desulphation, processes found to be non-related. Poly-l-ornithine and poly-dl-lysine increased the heparin uptake by about 33-fold, and histone produced up to 7.5-fold increase in the desulphation. The same polycations inhibited heparin desulphation by macrophage extracts.
AB - Heparin uptake and desulphation by cultured macrophages were investigated. Histones, polyamino-acids, protamine and eosinophil-basic protein stimulated both heparin uptake and desulphation, processes found to be non-related. Poly-l-ornithine and poly-dl-lysine increased the heparin uptake by about 33-fold, and histone produced up to 7.5-fold increase in the desulphation. The same polycations inhibited heparin desulphation by macrophage extracts.
UR - http://www.scopus.com/inward/record.url?scp=0018118428&partnerID=8YFLogxK
U2 - 10.1016/0304-4165(78)90210-6
DO - 10.1016/0304-4165(78)90210-6
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AN - SCOPUS:0018118428
VL - 544
SP - 69
EP - 76
JO - Biochimica et Biophysica Acta - General Subjects
JF - Biochimica et Biophysica Acta - General Subjects
SN - 0304-4165
IS - 1
ER -