Increased uptake and desulphaton of heparin by mouse macrophages in the presence of polycations

Ina Fabian; Ilan Bleiberg; Moshe Aronson

doi:10.1016/0304-4165(78)90210-6

Increased uptake and desulphaton of heparin by mouse macrophages in the presence of polycations

Ina Fabian, Ilan Bleiberg, Moshe Aronson

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Abstract

Heparin uptake and desulphation by cultured macrophages were investigated. Histones, polyamino-acids, protamine and eosinophil-basic protein stimulated both heparin uptake and desulphation, processes found to be non-related. Poly-l-ornithine and poly-dl-lysine increased the heparin uptake by about 33-fold, and histone produced up to 7.5-fold increase in the desulphation. The same polycations inhibited heparin desulphation by macrophage extracts.

Original language	English
Pages (from-to)	69-76
Number of pages	8
Journal	Biochimica et Biophysica Acta - General Subjects
Volume	544
Issue number	1
DOIs	https://doi.org/10.1016/0304-4165(78)90210-6
State	Published - 15 Nov 1978

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title = "Increased uptake and desulphaton of heparin by mouse macrophages in the presence of polycations",

abstract = "Heparin uptake and desulphation by cultured macrophages were investigated. Histones, polyamino-acids, protamine and eosinophil-basic protein stimulated both heparin uptake and desulphation, processes found to be non-related. Poly-l-ornithine and poly-dl-lysine increased the heparin uptake by about 33-fold, and histone produced up to 7.5-fold increase in the desulphation. The same polycations inhibited heparin desulphation by macrophage extracts.",

author = "Ina Fabian and Ilan Bleiberg and Moshe Aronson",

year = "1978",

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AU - Fabian, Ina

AU - Bleiberg, Ilan

AU - Aronson, Moshe

PY - 1978/11/15

Y1 - 1978/11/15

N2 - Heparin uptake and desulphation by cultured macrophages were investigated. Histones, polyamino-acids, protamine and eosinophil-basic protein stimulated both heparin uptake and desulphation, processes found to be non-related. Poly-l-ornithine and poly-dl-lysine increased the heparin uptake by about 33-fold, and histone produced up to 7.5-fold increase in the desulphation. The same polycations inhibited heparin desulphation by macrophage extracts.

AB - Heparin uptake and desulphation by cultured macrophages were investigated. Histones, polyamino-acids, protamine and eosinophil-basic protein stimulated both heparin uptake and desulphation, processes found to be non-related. Poly-l-ornithine and poly-dl-lysine increased the heparin uptake by about 33-fold, and histone produced up to 7.5-fold increase in the desulphation. The same polycations inhibited heparin desulphation by macrophage extracts.

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U2 - 10.1016/0304-4165(78)90210-6

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VL - 544

SP - 69

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JO - Biochimica et Biophysica Acta - General Subjects

JF - Biochimica et Biophysica Acta - General Subjects

SN - 0304-4165

IS - 1

ER -

Increased uptake and desulphaton of heparin by mouse macrophages in the presence of polycations

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