Increased thromboxane b2 generation and βthromboglobulin release from activated platelets in myotonic dystrophy

M. Zahavi, N. M. Bornstein, J. Zahavi, A. D. Korczyn

Research output: Contribution to journalArticlepeer-review

Abstract

Compared to normal controls, platelets from myotonic dystrophy (MyD) patients, released significantly more βthromboglobulin (βTG) and generated more thromboxane B2 (TXB2) when platelet aggregation was induced by ADP (1.5 μM) or epinephrine 1 μM. TXB2 generation in MyD platelets at 1 and 3 min was positively correlated (p < 0.05) to platelet aggregation (PA). This suggests that, 1 min after the addition of the PA inducers, the platelets of MyD patients are already at the second (irreversible) phase of PA. Together with our previous data, these results may indicate hyperactivity of platelets caused by a membrane abnormality in MyD.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalPlatelets
Volume4
Issue number1
DOIs
StatePublished - 1993

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