TY - JOUR
T1 - Increased spontaneous secretion of IL‐6 from B cells of patients with B chronic lymphatic leukaemia (B‐CLL) and autoimmunity
AU - LAHAT, N.
AU - AGHAI, E.
AU - MAROUN, B.
AU - KINARTY, A.
AU - QUITT, M.
AU - FROOM, P.
PY - 1991/8
Y1 - 1991/8
N2 - We studied B cells from 18 patients with B‐CLL, six of them with autoimmune haemolytic anaemia, for spontaneous secretion of IL‐6. Our aim was to determine whether the increased incidence of autoimmune disease found in B‐CLL patients is associated with enhanced spontaneous IL‐6 secretion. IL‐6 was measured by the effect of B cell supernatants on the proliferation of an IL‐6 dependent plasmacytoma cell line T1165. The highest IL‐6 values (7.4±1.8 U/ml) were measured in supernatants derived on day 3 of culture from lymphocytes of the six patients with B‐CLL and concomitant autoimmune disease. The maximal IL‐6 values for 10 patients with B‐CLL only were 2.8±0.3 U/ml and for 10 age‐matched controls, 0.8±0.3 U/ml (P < 0.01, each group compared with the other). We conclude that there is an association between B‐CLL, autoimmune disease and the spontaneous in vitro secretion of IL‐6. Further studies are needed to determine whether the IL‐6 secretion plays a role in the pathogenesis of autoimmune disease in patients with B‐CLL.
AB - We studied B cells from 18 patients with B‐CLL, six of them with autoimmune haemolytic anaemia, for spontaneous secretion of IL‐6. Our aim was to determine whether the increased incidence of autoimmune disease found in B‐CLL patients is associated with enhanced spontaneous IL‐6 secretion. IL‐6 was measured by the effect of B cell supernatants on the proliferation of an IL‐6 dependent plasmacytoma cell line T1165. The highest IL‐6 values (7.4±1.8 U/ml) were measured in supernatants derived on day 3 of culture from lymphocytes of the six patients with B‐CLL and concomitant autoimmune disease. The maximal IL‐6 values for 10 patients with B‐CLL only were 2.8±0.3 U/ml and for 10 age‐matched controls, 0.8±0.3 U/ml (P < 0.01, each group compared with the other). We conclude that there is an association between B‐CLL, autoimmune disease and the spontaneous in vitro secretion of IL‐6. Further studies are needed to determine whether the IL‐6 secretion plays a role in the pathogenesis of autoimmune disease in patients with B‐CLL.
KW - IL‐6
KW - chronic lymphatic leukaemia and autoimmunity
KW - secretion
UR - http://www.scopus.com/inward/record.url?scp=0025772901&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2249.1991.tb05723.x
DO - 10.1111/j.1365-2249.1991.tb05723.x
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C2 - 1864011
AN - SCOPUS:0025772901
SN - 0009-9104
VL - 85
SP - 302
EP - 306
JO - Clinical and Experimental Immunology
JF - Clinical and Experimental Immunology
IS - 2
ER -