Increased serotonin 5-HT2 receptor binding on blood platelets of suicidal men

Anat Biegon, Alexander Grinspoon, Batia Blumenfeld, Avraham Bleich, Alan Apter, Roberto Mester

Research output: Contribution to journalArticlepeer-review

Abstract

In search of a physiological marker of depression and suicidal behavior, serotonin receptors of the 5-HT2 type were studied on platelet membranes from 19 control and 22 suicidal subjects. All were young, drug - and medication free men (18-21-years-old). 5-HT2 receptor binding was assayed using tritiated ketanserine at two concentrations. Receptor binding in the suicidal subjects was significantly higher than controls at both concentrations, the mean difference being around 50%. A similar difference between patients with major depressive disorder and matched controls has been observed previously. These findings support the use of 5-HT2 receptors on platelets as a research and diagnostic tool in depression and suicide.

Original languageEnglish
Pages (from-to)165-167
Number of pages3
JournalPsychopharmacology
Volume100
Issue number2
DOIs
StatePublished - Feb 1990

Keywords

  • 5-HT2 receptors
  • Platelets
  • Serotonin
  • Suicide

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