TY - JOUR
T1 - Increased risk for early hypertriglyceridemia in small for gestational age preterm infants
AU - Rabinowicz, Shira
AU - Levkovitz, Orly
AU - Leibovitch, Leah
AU - Schushan-Eisen, Irit
AU - Morag, Iris
AU - Rosen, Chava
AU - Maayan-Metzger, Ayala
AU - Strauss, Tzipora
N1 - Publisher Copyright:
© 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2020/12
Y1 - 2020/12
N2 - Small for gestational age preterm are at increased risk for future metabolic syndrome. Early indication for the disrupted metabolism may be found in the perinatal period. We aimed to evaluate whether small for gestational age preterm infants are at increased risk for hypertriglyceridemia when treated with lipid emulsions, and to investigate the association between triglyceride levels and morbidity. Small for gestational age infants ≤ 34 weeks’ gestation age born during 2013–2016 were matched and compared with appropriate for gestational age counterparts. Triglyceride concentration > 250 mg/dL during treatment with parenteral nutrition was considered high. The study included 71 pairs of preterm infants. Hypertriglyceridemia was documented among 22.5% of the small for gestational age infants vs. 5.6% of the appropriate for gestational age infants (p = 0.007). Mean triglyceride levels were 194.4 ± 192.3 mg/dL and 99.9 ± 82.8 mg/dL, respectively (p < 0.001). Small for gestational age was predictive of hypertriglyceridemia (OR = 6.41; 95% CI 1.8–22.9). No significant association was found between triglyceride levels and morbidities in multivariate analysis. Conclusion: Small for gestational age preterm infants receiving lipid emulsions might be at a higher risk for hypertriglyceridemia. Routine monitoring of triglyceride levels will enable identification of the necessity for a slower increase in lipid emulsion therapy.What is Known:• Moderate and very preterm infants are routinely treated with lipid emulsions.• Small for gestational age (SGA) infants may have different metabolism, as they demonstrate higher risk for metabolic syndrome.What is New:• • SGA infants had a higher mean triglyceride level and more commonly had early hypertriglyceridemia (triglycerides > 250 mg/dL) compared with appropriate for gestational age infants treated with the same intravenous lipid dose. Small for gestational age was predictive of hypertriglyceridemia.• No significant association was found between triglyceride levels and morbidities in multivariate analysis.
AB - Small for gestational age preterm are at increased risk for future metabolic syndrome. Early indication for the disrupted metabolism may be found in the perinatal period. We aimed to evaluate whether small for gestational age preterm infants are at increased risk for hypertriglyceridemia when treated with lipid emulsions, and to investigate the association between triglyceride levels and morbidity. Small for gestational age infants ≤ 34 weeks’ gestation age born during 2013–2016 were matched and compared with appropriate for gestational age counterparts. Triglyceride concentration > 250 mg/dL during treatment with parenteral nutrition was considered high. The study included 71 pairs of preterm infants. Hypertriglyceridemia was documented among 22.5% of the small for gestational age infants vs. 5.6% of the appropriate for gestational age infants (p = 0.007). Mean triglyceride levels were 194.4 ± 192.3 mg/dL and 99.9 ± 82.8 mg/dL, respectively (p < 0.001). Small for gestational age was predictive of hypertriglyceridemia (OR = 6.41; 95% CI 1.8–22.9). No significant association was found between triglyceride levels and morbidities in multivariate analysis. Conclusion: Small for gestational age preterm infants receiving lipid emulsions might be at a higher risk for hypertriglyceridemia. Routine monitoring of triglyceride levels will enable identification of the necessity for a slower increase in lipid emulsion therapy.What is Known:• Moderate and very preterm infants are routinely treated with lipid emulsions.• Small for gestational age (SGA) infants may have different metabolism, as they demonstrate higher risk for metabolic syndrome.What is New:• • SGA infants had a higher mean triglyceride level and more commonly had early hypertriglyceridemia (triglycerides > 250 mg/dL) compared with appropriate for gestational age infants treated with the same intravenous lipid dose. Small for gestational age was predictive of hypertriglyceridemia.• No significant association was found between triglyceride levels and morbidities in multivariate analysis.
KW - Hypertriglyceridemia
KW - Metabolism
KW - Nutrition
KW - Small for gestational age
KW - Triglycerides
UR - http://www.scopus.com/inward/record.url?scp=85089260039&partnerID=8YFLogxK
U2 - 10.1007/s00431-020-03764-8
DO - 10.1007/s00431-020-03764-8
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C2 - 32770487
AN - SCOPUS:85089260039
SN - 0340-6199
VL - 179
SP - 1873
EP - 1879
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
IS - 12
ER -