Increased prevalence of diabetes-related autoantibodies in celiac disease

M. J. Rapoport, T. Bistritzer, O. Vardi, E. Broide, A. Azizi, P. Vardi

Research output: Contribution to journalArticlepeer-review

Abstract

Forty-four nondiabetic patients with celiac disease (CD) were examined for the presence of insulin-dependent diabetes mellitus (IDDM)-related autoantibodies. Islet cell antibodies (ICA) were detected in 2 of 44 (4.5%). None of the 200 age- and sex-matched healthy controls was ICA positive (p < 0.005). Competitive antiinsulin antibodies (CIAA) were detected in 1 of 44 (2.5%) patients. First-phase insulin reserve (FPIR), stimulated insulin reserve (SIR), and glycosylated hemoglobin(GHB) levels were normal in the autoantibody-positive patients. Our data suggest that, like first-degree relatives of IDDM patients, CD patients are characterized by an increased prevalence of diabetes-related autoantibodies. Further follow-up is needed to determine whether the presence of these autoantibodies in nondiabetic CD patients predicts future IDDM.

Original languageEnglish
Pages (from-to)524-527
Number of pages4
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume23
Issue number5
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • Autoantibodies
  • Celiac disease
  • Insulin-dependent diabetes mellitus

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