Increased platelet vesicular monoamine transporter density in adult schizophrenia patients

Michal Zucker, Avi Valevski, Avraham Weizman, Moshe Rehavi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Vesicular monoamine transporter (VMAT2) plays a major role in the synaptic accumulation and release of monoamines. In the present study, we assessed high affinity [3H]dihydrotetrabenazine binding to platelet VMAT2 in a group of treated (n=9) and untreated (n=4) patients with schizophrenia and age- and sex-matched controls. Significantly elevated platelet VMAT2 density (Bmax) (53%, P<0.0001) was observed in the mixed population of schizophrenia patients. The affinity of the ligand (Kd) to platelet VMAT2 was similar in both groups. The increased platelet VMAT2 density may indicate a schizophrenia-related hyperactivity of the monoaminergic system or an adaptive response to chronic drug treatment.

Original languageEnglish
Pages (from-to)343-347
Number of pages5
JournalEuropean Neuropsychopharmacology
Volume12
Issue number4
DOIs
StatePublished - 2002

Keywords

  • Dihydrotetrabenazine
  • Monoamines
  • Platelet
  • Schizophrenia
  • Vesicular monoamine transporter

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