Increased platelet vesicular monoamine transporter density in adult schizophrenia patients

Michal Zucker; Avi Valevski; Avraham Weizman; Moshe Rehavi

doi:10.1016/S0924-977X(02)00041-X

Increased platelet vesicular monoamine transporter density in adult schizophrenia patients

Michal Zucker, Avi Valevski, Avraham Weizman, Moshe Rehavi^*

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Vesicular monoamine transporter (VMAT2) plays a major role in the synaptic accumulation and release of monoamines. In the present study, we assessed high affinity [³H]dihydrotetrabenazine binding to platelet VMAT2 in a group of treated (n=9) and untreated (n=4) patients with schizophrenia and age- and sex-matched controls. Significantly elevated platelet VMAT2 density (B_max) (53%, P<0.0001) was observed in the mixed population of schizophrenia patients. The affinity of the ligand (K_d) to platelet VMAT2 was similar in both groups. The increased platelet VMAT2 density may indicate a schizophrenia-related hyperactivity of the monoaminergic system or an adaptive response to chronic drug treatment.

Original language	English
Pages (from-to)	343-347
Number of pages	5
Journal	European Neuropsychopharmacology
Volume	12
Issue number	4
DOIs	https://doi.org/10.1016/S0924-977X(02)00041-X
State	Published - 2002

Keywords

Dihydrotetrabenazine
Monoamines
Platelet
Schizophrenia
Vesicular monoamine transporter

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10.1016/S0924-977X(02)00041-X

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AU - Zucker, Michal

AU - Valevski, Avi

AU - Weizman, Avraham

AU - Rehavi, Moshe

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AB - Vesicular monoamine transporter (VMAT2) plays a major role in the synaptic accumulation and release of monoamines. In the present study, we assessed high affinity [3H]dihydrotetrabenazine binding to platelet VMAT2 in a group of treated (n=9) and untreated (n=4) patients with schizophrenia and age- and sex-matched controls. Significantly elevated platelet VMAT2 density (Bmax) (53%, P<0.0001) was observed in the mixed population of schizophrenia patients. The affinity of the ligand (Kd) to platelet VMAT2 was similar in both groups. The increased platelet VMAT2 density may indicate a schizophrenia-related hyperactivity of the monoaminergic system or an adaptive response to chronic drug treatment.

KW - Dihydrotetrabenazine

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KW - Platelet

KW - Schizophrenia

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Increased platelet vesicular monoamine transporter density in adult schizophrenia patients

Abstract

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