Increased platelet aggregation and release reaction in myotonic dystrophy

N. M. Bornstein; M. Zahavi; A. D. Korczyn; J. Zahavi

doi:10.1016/0022-510X(88)90128-1

Increased platelet aggregation and release reaction in myotonic dystrophy

N. M. Bornstein, M. Zahavi, A. D. Korczyn^*, J. Zahavi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Platelet aggregation (PA) induced by (-)-epinephrine and adenosine diphosphate (ADP) was studied in 16 patients with myotonic dystrophy (MyD) and 14 healthy subjects. Plasma β-thromboglobulin level (β-TG), a useful marker of in vivo platelet release reaction, as well as in vitro 5-[¹⁴C]hydroxytryptamine (5-HT) release, were also studied. The extent of PA induced by (-)-epinephrine at 1 and 3 min and by ADP at 3 min was significantly higher in the patients than in controls. Plasma β-TG and ADP-or epinephrine-induced platelet 5-HT release were also increased in MyD patients. These results suggest that an abnormality in release as well as in α₂-receptor functioning occurs in the platelets of MyD patients. The relation of this abnormality to changes in Ca²⁺ fluxes through the platelet membrane is discussed.

Original language	English
Pages (from-to)	239-246
Number of pages	8
Journal	Journal of the Neurological Sciences
Volume	84
Issue number	2-3
DOIs	https://doi.org/10.1016/0022-510X(88)90128-1
State	Published - Apr 1988

Keywords

Adrenergic receptors
Myotonic dystrophy
Platelet aggregation
Release reaction

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10.1016/0022-510X(88)90128-1

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title = "Increased platelet aggregation and release reaction in myotonic dystrophy",

abstract = "Platelet aggregation (PA) induced by (-)-epinephrine and adenosine diphosphate (ADP) was studied in 16 patients with myotonic dystrophy (MyD) and 14 healthy subjects. Plasma β-thromboglobulin level (β-TG), a useful marker of in vivo platelet release reaction, as well as in vitro 5-[14C]hydroxytryptamine (5-HT) release, were also studied. The extent of PA induced by (-)-epinephrine at 1 and 3 min and by ADP at 3 min was significantly higher in the patients than in controls. Plasma β-TG and ADP-or epinephrine-induced platelet 5-HT release were also increased in MyD patients. These results suggest that an abnormality in release as well as in α2-receptor functioning occurs in the platelets of MyD patients. The relation of this abnormality to changes in Ca2+ fluxes through the platelet membrane is discussed.",

keywords = "Adrenergic receptors, Myotonic dystrophy, Platelet aggregation, Release reaction",

author = "Bornstein, {N. M.} and M. Zahavi and Korczyn, {A. D.} and J. Zahavi",

year = "1988",

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AU - Bornstein, N. M.

AU - Zahavi, M.

AU - Korczyn, A. D.

AU - Zahavi, J.

PY - 1988/4

Y1 - 1988/4

N2 - Platelet aggregation (PA) induced by (-)-epinephrine and adenosine diphosphate (ADP) was studied in 16 patients with myotonic dystrophy (MyD) and 14 healthy subjects. Plasma β-thromboglobulin level (β-TG), a useful marker of in vivo platelet release reaction, as well as in vitro 5-[14C]hydroxytryptamine (5-HT) release, were also studied. The extent of PA induced by (-)-epinephrine at 1 and 3 min and by ADP at 3 min was significantly higher in the patients than in controls. Plasma β-TG and ADP-or epinephrine-induced platelet 5-HT release were also increased in MyD patients. These results suggest that an abnormality in release as well as in α2-receptor functioning occurs in the platelets of MyD patients. The relation of this abnormality to changes in Ca2+ fluxes through the platelet membrane is discussed.

AB - Platelet aggregation (PA) induced by (-)-epinephrine and adenosine diphosphate (ADP) was studied in 16 patients with myotonic dystrophy (MyD) and 14 healthy subjects. Plasma β-thromboglobulin level (β-TG), a useful marker of in vivo platelet release reaction, as well as in vitro 5-[14C]hydroxytryptamine (5-HT) release, were also studied. The extent of PA induced by (-)-epinephrine at 1 and 3 min and by ADP at 3 min was significantly higher in the patients than in controls. Plasma β-TG and ADP-or epinephrine-induced platelet 5-HT release were also increased in MyD patients. These results suggest that an abnormality in release as well as in α2-receptor functioning occurs in the platelets of MyD patients. The relation of this abnormality to changes in Ca2+ fluxes through the platelet membrane is discussed.

KW - Adrenergic receptors

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KW - Platelet aggregation

KW - Release reaction

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Increased platelet aggregation and release reaction in myotonic dystrophy

Abstract

Keywords

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