Increased platelet aggregation and release reaction in myotonic dystrophy

N. M. Bornstein, M. Zahavi, A. D. Korczyn, J. Zahavi

Research output: Contribution to journalArticlepeer-review

Abstract

Platelet aggregation (PA) induced by (-)-epinephrine and adenosine diphosphate (ADP) was studied in 16 patients with myotonic dystrophy (MyD) and 14 healthy subjects. Plasma β-thromboglobulin level (β-TG), a useful marker of in vivo platelet release reaction, as well as in vitro 5-[14C]hydroxytryptamine (5-HT) release, were also studied. The extent of PA induced by (-)-epinephrine at 1 and 3 min and by ADP at 3 min was significantly higher in the patients than in controls. Plasma β-TG and ADP-or epinephrine-induced platelet 5-HT release were also increased in MyD patients. These results suggest that an abnormality in release as well as in α2-receptor functioning occurs in the platelets of MyD patients. The relation of this abnormality to changes in Ca2+ fluxes through the platelet membrane is discussed.

Original languageEnglish
Pages (from-to)239-246
Number of pages8
JournalJournal of the Neurological Sciences
Volume84
Issue number2-3
DOIs
StatePublished - Apr 1988

Keywords

  • Adrenergic receptors
  • Myotonic dystrophy
  • Platelet aggregation
  • Release reaction

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