TY - JOUR
T1 - Increased plasma levels and blunted effects of brain natriuretic peptide in rats with congestive heart failure
AU - Hoffman, Aaron
AU - Grossman, Ehud
AU - Keiser, Harry R.
PY - 1991/7
Y1 - 1991/7
N2 - The hemodynamic and renal effects of brain natriuretic peptide (BNP) were studied in conscious rats with experimental congestive heart failure (CHF) produced by an aortocaval fistula. The peptide had potent hypotensive, diuretic, and natriuretic effects in control rats, all of which were abolished in CHF. Plasma levels of BNP increased time-dependently during the development of CHF, and were more than four-fold higher in sodium retaining rats than in control rats. The data suggest that BNP secretion from the atria is increased in CHF, and that resistance to BNP, in addition to the relative resistance to atrial natriuretic factor, may contribute to sodium retention in CHF. Am J Hy- pertens 1991;4:597-601.
AB - The hemodynamic and renal effects of brain natriuretic peptide (BNP) were studied in conscious rats with experimental congestive heart failure (CHF) produced by an aortocaval fistula. The peptide had potent hypotensive, diuretic, and natriuretic effects in control rats, all of which were abolished in CHF. Plasma levels of BNP increased time-dependently during the development of CHF, and were more than four-fold higher in sodium retaining rats than in control rats. The data suggest that BNP secretion from the atria is increased in CHF, and that resistance to BNP, in addition to the relative resistance to atrial natriuretic factor, may contribute to sodium retention in CHF. Am J Hy- pertens 1991;4:597-601.
KW - Atrial natriuretic factor
KW - Brain natriuretic peptide
KW - Congestive heart failure
KW - Radioimmunoassay
KW - Renal function
UR - http://www.scopus.com/inward/record.url?scp=0025779018&partnerID=8YFLogxK
U2 - 10.1093/ajh/4.7.597
DO - 10.1093/ajh/4.7.597
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C2 - 1831369
AN - SCOPUS:0025779018
SN - 0895-7061
VL - 4
SP - 597
EP - 601
JO - American Journal of Hypertension
JF - American Journal of Hypertension
IS - 7
ER -