Increased plasma levels and blunted effects of brain natriuretic peptide in rats with congestive heart failure

Aaron Hoffman, Ehud Grossman, Harry R. Keiser

Research output: Contribution to journalArticlepeer-review

Abstract

The hemodynamic and renal effects of brain na­triuretic peptide (BNP) were studied in conscious rats with experimental congestive heart failure (CHF) produced by an aortocaval fistula. The pep­tide had potent hypotensive, diuretic, and natriure­tic effects in control rats, all of which were abol­ished in CHF. Plasma levels of BNP increased time-dependently during the development of CHF, and were more than four-fold higher in sodium re­taining rats than in control rats. The data suggest that BNP secretion from the atria is increased in CHF, and that resistance to BNP, in addition to the relative resistance to atrial natriuretic factor, may contribute to sodium retention in CHF. Am J Hy- pertens 1991;4:597-601.

Original languageEnglish
Pages (from-to)597-601
Number of pages5
JournalAmerican Journal of Hypertension
Volume4
Issue number7
DOIs
StatePublished - Jul 1991

Keywords

  • Atrial na­triuretic factor
  • Brain natriuretic peptide
  • Congestive heart failure
  • Radioimmunoassay
  • Renal func­tion

Fingerprint

Dive into the research topics of 'Increased plasma levels and blunted effects of brain natriuretic peptide in rats with congestive heart failure'. Together they form a unique fingerprint.

Cite this