Increased plasma and optic nerve levels of IL-6, TNF-α, and MIP-2 following induction of ischemic optic neuropathy in mice

Bat Chen R. Avraham, Gad Dotan, Murat Hasanreisoglu, Michal Kramer, Yehudit Monselise, Yoram Cohen, Dov Weinberger, Nitza Goldenberg-Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To investigate levels of proinflammatory cytokines in a mouse model of anterior ischemic optic neuropathy (rAION). Methods: AION was induced in C57/BL6 mice and levels of IL-6, TNF-α, and MIP-2 were measured in plasma by ELISA and in the optic nerves by RT-PCR at predetermined intervals. Results: Plasma: IL-6 levels were elevated immediately after rAION induction and decreased gradually thereafter. TNF-α showed an early peak on day 1 and again from day 21. MIP-2 levels were increased until day 7. Optic nerve: IL-6, TNF-α, and MIP-2 levels increased within a few hours and then decreased gradually. IL-6 had a second peak on day 3. Conclusions: Proinflammatory cytokines may play a role in the pathogenesis of rAION.

Original languageEnglish
Pages (from-to)395-401
Number of pages7
JournalCurrent Eye Research
Volume33
Issue number4
DOIs
StatePublished - Apr 2008

Keywords

  • Anterior ischemic optic neuropathy
  • IL-6
  • MIP-2
  • Proinflammatory cytokines
  • TNF-α

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