Increased number of peripheral blood CD34+ cells in lithium-treated patients

Ami Ballin, Dan Lehman, Pinkhas Sirota, Ulia Litvinjuk, Dina Meytes

Research output: Contribution to journalArticlepeer-review

Abstract

Eight adult patients with bipolar disorder were prospectively examined to find whether lithium carbonate increased their peripheral blood CD34+ haemopoietic stem cells. Following lithium therapy for 3-4 weeks their neutrophil counts increased by a mean of 88% (from 4625 ± 1350 x 109/l, mean ± SD pretreatment, to a peak of 8300 ± 3910 x 109/l). Concommitantly, there was a significant increment in their CD34+ cells (from 0.11 ± 0.01% to a peak of 0.18 ± 0.08%). There was a significant correlation between the rise in neutrophil count and that of the CD34+ cells (r=0.795, P=0.019). Lithium therapy may be used to mobilize peripheral blood CD34+ cells for marrow transplantation.

Original languageEnglish
Pages (from-to)219-221
Number of pages3
JournalBritish Journal of Haematology
Volume100
Issue number1
DOIs
StatePublished - 1998

Keywords

  • Bone marrow transplantation
  • CD34 cells
  • Lithium
  • Neutrophilia

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